General Dermatology Archives - Dermatology Advisor

IV Pulse Dexamethasone Plus [KL1] Topical Corticosteroids for Severe Pediatric Alopecia Areata

By

Emily Pond

November 4, 2019

Researchers compared 1-day intravenous dexamethasone pulses with 3-day pulses in a small cohort of children and adolescents with severe AA.

Urticaria is common during pregnancy and presents as wheals, angioedema, or a combination of the two. Chronic cases last for 6 weeks or more.3,9 Urticaria is not specific to pregnancy, and data are insufficient to determine whether pregnancy improves or exacerbates the condition in women with preexisting chronic urticaria. However, chronic urticaria is twice as common in women, and evidence suggests sex hormones may affect urticaria in some women.2 Standard treatment in pregnant women with urticaria is oral antihistamines.2,9 No antihistamines have been shown to pose a risk for fetal harm. Chlorpheniramine, diphenhydramine, loratadine, and cetirizine are preferred.2,3 Expectant mothers should avoid using antihistamines late in pregnancy because they can stimulate uterine contractions and newborn infants may experience withdrawal.2

General Dermatology

Ligelizumab Offers Greater Symptom Control of Chronic Spontaneous Urticaria Than Omalizumab

By

Brandon May

October 31, 2019

More patients treated with ligelizumab achieved complete control of urticarial symptoms than patients who received omalizumab, a study finds.

Molluscum contagiosum occurs in approximately 5% to 18% of HIV-infected people, but is becoming rare in areas of the world with good access to highly effective antiretroviral therapies (HAART).16 It is caused by an infection of the epidermal keratinocytes by the molluscum contagiosum virus, a double-stranded DNA virus belonging to the Poxviridae family.16,17 Patients present with small (≤5 mm in diameter), raised lesions that are usually white, pink, or flesh colored with a dimple or pit in the center.17 The lesions are typically smooth, firm, and pearly appearing, and can affect any area of the body, although they are rarely found on the palms or soles. They may occur as solitary lesions or in groups and typically resolve within 6 to 12 months without any scarring.17 Genital lesions may take longer to resolve, and healing times up to 4 years have been reported.16,17 Photo Credit: Medical Images RM/AL LAMME.

General Dermatology

Berdazimer Sodium Plus Hydrogel Provides Rapid Lesion Clearance in Molluscum Contagiosum

By

Brandon May

October 31, 2019

SB206 12% represents a well-tolerated topical treatment for molluscum contagiosum that can be applied at home by patients or caregivers, solving an unmet medical need.

General Dermatology

Onchocerciasis Treatment With Ivermectin: Results Support Semiannual Mass Drug Administration

By

Sweta Gupta

October 31, 2019

While ivermectin plus albendazole was not superior in the treatment of onchocerciasis compared with ivermectin alone, semiannual treatment with or without albendazole was superior to annual treatment for suppressing microfilaria in the skin.

General Dermatology

Tofacitinib Effective in Treatment of Chronic Pruritus With Rheumatoid Arthritis

By

Emily Pond

October 30, 2019

Investigators evaluated the treatment of chronic pruritus with tofacitinib in patients with concomitant rheumatoid arthritis.

General Dermatology

Clinical Manifestations of Antisynthetase Syndrome: Skin, Muscle, and Lung

By

Emily Pond

October 28, 2019

Patients with ASS often present with a psoriasiform tissue reaction in the hand lesions and fasciitis-dominant myopathy; the relatives of patients with ASS are at high risk for collagen diseases.

General Dermatology

Impact of Tightening Opioid Regulations in Patients With Chronic Pain

By

Tyler Rice

October 28, 2019

Patients on long-term opioid treatment for chronic pain reported experiencing negative physical side effects, emotional distress, and degraded relationships with their primary care provider.

General Dermatology

Rituximab Compared With Mycophenolate Mofetil in Pemphigus Vulgaris Trial

By

Diana Ernst, RPh

October 17, 2019

Rituximab was found to be superior to mycophenolate mofetil (MMF) in adult patients with severe pemphigus vulgaris, according to new phase 3 trial data.

General Dermatology

Persistent Diarrhea, Delirium, and Beefy Tongue: Is It Pellagra?

By

Diana Ernst, RPh

October 15, 2019

Severe micronutrient deficiency should be considered in the differential diagnosis in complex cases where a clear etiology is unknown.

General Dermatology

First Treatment for Erythropoietic Protoporphyria Gets FDA Approval

By

Diana Ernst, RPh

October 11, 2019

The FDA has approved Scenesse for the treatment of patients with erythropoietic protoporphyria, a rare genetic metabolic disorder in which patients experience severe biochemical reactions following light exposure.