Atopic Dermatitis Archives - Dermatology Advisor

Atopic dermatitis is a serious condition that has been reported to affect between 30% and 50% of people who are HIV positive vs ≤20% of those who are HIV negative.2 The condition has been associated with elevated immunoglobulin E levels, eosinophilia, and possible Th1-Th2 imbalances.2,12 Because nearly all patients with AIDS demonstrate Th1-Th2 imbalances, they are at particularly high risk for atopic dermatitis.2 Patients generally present with chronic, red, thick, lichenified plaques and severe, incessant pruritus that can have an impact on daily function and sleep and reduce quality of life significantly.13 Isolated pruritic papules are sometimes observed. The hands, face, and eyelids, and areas of the body with large skin folds are most often affected; however, inflammatory flare-ups can affect the entire body and might necessitate hospitalization.13

Dupilumab Reduces Atopic Dermatitis Flares

By

Brandon May

July 9, 2020

Dupilumab provides long-term control of AD and prevents disease flares, which may help reduce the need for escalation and/or intensification of therapy.

Dermatitis

Quantitative Changes Accompany Transition from Nonlesional to Acute to Chronic Inflammation in AD

By

Brandon May

July 8, 2020

The sequence of AD progression from acute to chronic stages, with progressively heightened inflammatory response for all major immune axes, has been delineated.

Dermatitis

Atopic Dermatitis in Children: Monitor the Comorbidities

By

Emily Pond

July 7, 2020

Childhood atopic dermatitis is often associated with neuropsychiatric, visual, cardio-metabolic and autoimmune disorder, which should be monitored to improve patient outcome.

Dermatitis

A Bidirectional Relationship Between Atopic Dermatitis and IBD?

By

Brandon May

July 7, 2020

Support is given for an association between atopic dermatitis and inflammatory bowel disease, and underscores the value of a multidisciplinary treatment approach.

Dermatitis

Topical Timolol for Recalcitrant Hand Eczema

By

Emily Pond

July 6, 2020

Topical timolol may represent a more accessible treatment for recalcitrant fissures and erosions of chronic hand eczema.

Dermatitis

Increased Bathing Frequency Associated With Skin Barrier Dysfunction, Atopic Dermatitis in Infants

By

Emily Pond

July 6, 2020

Data suggest that increased bathing frequency may negatively affect the developing skin barriers of infants.

Dermatitis

Improvements in Skin Clearance, Itch Observed With Upadacitinib in Atopic Dermatitis Study

By

Brian Park, PharmD

June 25, 2020

Topline results from a phase 3 study evaluating upadacitinib monotherapy in patients aged ≥12 years with moderate to severe atopic dermatitis (AD) showed the treatment was associated with significant improvement in skin clearance.

AAD 2020

Abrocitinib Consistent, Superior for Treatment of AD in Phase 3 and 2b Trials

By

Brandon May

June 22, 2020

Consistent efficacy outcomes of abrocitinib for the treatment of patients with moderate to severe atopic dermatitis were demonstrated in phase 3 and phase 2B studies.

AAD 2020

Intranasal Butorphanol Effectively Reduces Pruritus

By

Brandon May

June 22, 2020

One of the largest case series of intranasal butorphanol rescue therapy in treating intractable itch demonstrates success.

Dermatitis

Positive Results With Abrocitinib in Adolescent Atopic Dermatitis Trial

By

Brian Park, PharmD

June 17, 2020

Positive topline results were announced from the phase 3 JADE TEEN study evaluating abrocitinib (Pfizer), a Janus Kinase (JAK) inhibitor, in patients aged 12 to <18 years with moderate to severe atopic dermatitis who were also on background topical therapy.