Melanoma

Nomogram Predicts Melanoma Recurrence Risk After Negative Sentinel Node Biopsy

Nomogram Predicts Melanoma Recurrence Risk After Negative Sentinel Node Biopsy

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Current treatment guidelines do not adequately cover what kind of surveillance and treatment should apply to patients with melanoma after a negative sentinel node biopsy.

High Melanoma Care Costs With Ipilimumab

High Melanoma Care Costs With Ipilimumab

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Melanoma costs have increased as a result of the introduction of ipilimumab.

Mucosal Melanoma Survival Rates Determined by Stage and Location

Mucosal Melanoma Survival Rates Determined by Stage and Location

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Stage at diagnosis is an independent risk factor for survival from mucosal melanoma, but tumor thickness and race/ethnicity are not, according to a new study.

Possible Predictors of Sentinel Lymph Node Positivity in Thin Melanomas

Possible Predictors of Sentinel Lymph Node Positivity in Thin Melanomas

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Gender, age, and Breslow thickness are significant predictors for sentinel lymph node biopsy positivity in thin melanoma.

Observation May Be Sufficient Management Option for Excised Moderately Dysplastic Nevi

Observation May Be Sufficient Management Option for Excised Moderately Dysplastic Nevi

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Observation of moderately dysplastic nevi excisionally biopsied with positive histologic margins may be an effective management option.

Risk for Nevus Development in Children Aged 3 to 16 Years

Risk for Nevus Development in Children Aged 3 to 16 Years

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Researchers examine nevus development in children age 3 to 17 years to analyze acquisition patterns for total nevus counts and counts on body sites exposed to ultraviolet light.

Inconsistent Association Between Malignant Melanoma and In Vitro Fertilization

Inconsistent Association Between Malignant Melanoma and In Vitro Fertilization

Women included in the studies had been diagnosed with infertility, defined as the inability to conceive for >12 months or another similar reproductive disorder.

Novel Immunotherapy May Increase Survival in Melanoma With Brain Metastases

Novel Immunotherapy May Increase Survival in Melanoma With Brain Metastases

Checkpoint blockade immunotherapy (CBI) is associated with significant increases in overall survival (OS) in a real-world population of patients undergoing treatment for melanoma brain metastases (MBM).

Age, Education Predict Skin Protection Following Melanoma Diagnosis

Age, Education Predict Skin Protection Following Melanoma Diagnosis

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Participants with a history of melanoma with inadequate sunscreen use doubled their risk for another primary melanoma within the next 2 years.

Predictive Scoring Model Effectively Differentiates Between Subungual Melanoma in <i>Situ</i>, Longitudinal Melanonychia

Predictive Scoring Model Effectively Differentiates Between Subungual Melanoma in Situ, Longitudinal Melanonychia

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A predictive scoring model that incorporated dermoscopic characteristics of SMIS was evaluated.

Early Identification of Nail Unit Melanoma Leads to Good Prognosis

Early Identification of Nail Unit Melanoma Leads to Good Prognosis

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Investigators examine epidemiologic, histologic, and clinical features of in situ nail unit melanoma.

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Patient Interest Fairly High for Melanoma Genetic Risk Testing

Reduced interest seen in minority and less educated populations

Melanoma Risk Differs in Men, Women With <i>MC1R</i> Variants

Melanoma Risk Differs in Men, Women With MC1R Variants

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Further investigation might eventually lead to sex-dependent prevention strategies and appropriate therapy.

FDA Accepts sBLA for Pembrolizumab as Adjuvant Therapy for Melanoma

FDA Accepts sBLA for Pembrolizumab as Adjuvant Therapy for Melanoma

If approved, the new indication could mean pembrolizumab could be used for patients with melanoma.

AJCC Cancer Staging Manual 8th Edition Improves on Reproducibility, Concordance in Melanoma Staging

AJCC Cancer Staging Manual 8th Edition Improves on Reproducibility, Concordance in Melanoma Staging

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Although the AJCC 8 has improvements compared with AJCC 7, concordance and reproducibility remain low.

Smartphone App Effectively Teaches Visual Diagnosis of Melanoma

Smartphone App Effectively Teaches Visual Diagnosis of Melanoma

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A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.

Convolutional Neural Network Tops Clinicians for Melanoma ID

Convolutional Neural Network Tops Clinicians for Melanoma ID

Researchers trained and validated Google's Inception v4 CNN architecture using dermoscopic images and corresponding diagnoses.

Tafinlar + Mekinist Approved for Adjuvant Tx of Melanoma With BRAF V600 Mutation

Tafinlar + Mekinist Approved for Adjuvant Tx of Melanoma With BRAF V600 Mutation

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Approval was based on COMBI-AD, an international, multi-center, randomized, double-blind, placebo-controlled trial in 870 patients with Stage III melanoma with BRAF V600E or V600K mutations, and pathologic involvement of regional lymph node(s).

Link Between Chronic Aspirin Use and Malignant Melanoma

Link Between Chronic Aspirin Use and Malignant Melanoma

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Further investigation into the link between chronic, once-daily aspirin use and malignant melanoma is warranted.

Males With <i>BRCA</i> Mutations Have Increased Risk of Certain Cancers

Males With BRCA Mutations Have Increased Risk of Certain Cancers

Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers.

Marital Status Tied to Earlier Presentation of Melanoma

Marital Status Tied to Earlier Presentation of Melanoma

For patients with localized melanoma, marital status is associated with earlier presentation.

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

Pembrolizumab is associated with significantly longer recurrence-free survival than placebo as adjuvant therapy for high-risk stage III melanoma.

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

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Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.

Melanocytic Skin Lesions Best Interpreted By Experienced, Specialized Pathologists

Melanocytic Skin Lesions Best Interpreted By Experienced, Specialized Pathologists

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Pathologist characteristics, including level of experience and training, were analyzed in association with these assessments using multivariable logistic regression modeling.

Tumor-Infiltrating Lymphocytes Predict Melanoma Prognosis in Men

Tumor-Infiltrating Lymphocytes Predict Melanoma Prognosis in Men

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The study may be limited by misclassification bias resulting from potential variability in tumor-infiltrating lymphocyte (TIL) classification, as well as selection bias resulting from the inclusion of only patients with TIL data.

Encorafenib, Binimetinib May Be Effective in <i>BRAF</i>-Mutant Melanoma

Encorafenib, Binimetinib May Be Effective in BRAF-Mutant Melanoma

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One death possibly related to treatment was, however, noted in the combination group.

Self-Examination Key to Fewer Follow-Up Visits After Melanoma Excision

Self-Examination Key to Fewer Follow-Up Visits After Melanoma Excision

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Higher stage of disease, having melanoma on a limb, living with others rather than living alone, not having private health insurance, and consulting with a specialist for another chronic medical condition were independently associated with a preference for fewer follow-up visits.

USPSTF: Behavioral Counseling for Skin Cancer Prevention Beneficial in Younger Patients

USPSTF: Behavioral Counseling for Skin Cancer Prevention Beneficial in Younger Patients

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There is sufficient evidence indicating that behavioral counseling interventions lead to a moderate increase in sun protection behaviors among individuals with fair skin types aged 6 months to 24 years.

No Survival Benefit in Melanoma With Adjuvant Vemurafenib

No Survival Benefit in Melanoma With Adjuvant Vemurafenib

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Vemurafenib adjuvant therapy does not improve disease-free survival among patients with resected stage IIC to IIIB melanoma.

Sentinel Node Biopsy vs Breslow Thickness for Melanoma Prognosis: Which is Better?

Sentinel Node Biopsy vs Breslow Thickness for Melanoma Prognosis: Which is Better?

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Both Breslow thickness and sentinel lymph node status were statistically significant in predicting cutaneous melanoma.

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