Women included in the studies had been diagnosed with infertility, defined as the inability to conceive for >12 months or another similar reproductive disorder.
Checkpoint blockade immunotherapy (CBI) is associated with significant increases in overall survival (OS) in a real-world population of patients undergoing treatment for melanoma brain metastases (MBM).
Participants with a history of melanoma with inadequate sunscreen use doubled their risk for another primary melanoma within the next 2 years.
Predictive Scoring Model Effectively Differentiates Between Subungual Melanoma in Situ, Longitudinal MelanonychiaAugust 21, 2018
A predictive scoring model that incorporated dermoscopic characteristics of SMIS was evaluated.
Investigators examine epidemiologic, histologic, and clinical features of in situ nail unit melanoma.
Reduced interest seen in minority and less educated populations
Further investigation might eventually lead to sex-dependent prevention strategies and appropriate therapy.
If approved, the new indication could mean pembrolizumab could be used for patients with melanoma.
Although the AJCC 8 has improvements compared with AJCC 7, concordance and reproducibility remain low.
A smartphone application is a more effective learning tool for accurately diagnosing melanoma compared with traditional, rule-based methods.
Researchers trained and validated Google's Inception v4 CNN architecture using dermoscopic images and corresponding diagnoses.
Approval was based on COMBI-AD, an international, multi-center, randomized, double-blind, placebo-controlled trial in 870 patients with Stage III melanoma with BRAF V600E or V600K mutations, and pathologic involvement of regional lymph node(s).
Further investigation into the link between chronic, once-daily aspirin use and malignant melanoma is warranted.
Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers.
For patients with localized melanoma, marital status is associated with earlier presentation.
Pembrolizumab is associated with significantly longer recurrence-free survival than placebo as adjuvant therapy for high-risk stage III melanoma.
Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.
Pathologist characteristics, including level of experience and training, were analyzed in association with these assessments using multivariable logistic regression modeling.
The study may be limited by misclassification bias resulting from potential variability in tumor-infiltrating lymphocyte (TIL) classification, as well as selection bias resulting from the inclusion of only patients with TIL data.
One death possibly related to treatment was, however, noted in the combination group.
Higher stage of disease, having melanoma on a limb, living with others rather than living alone, not having private health insurance, and consulting with a specialist for another chronic medical condition were independently associated with a preference for fewer follow-up visits.
There is sufficient evidence indicating that behavioral counseling interventions lead to a moderate increase in sun protection behaviors among individuals with fair skin types aged 6 months to 24 years.
Vemurafenib adjuvant therapy does not improve disease-free survival among patients with resected stage IIC to IIIB melanoma.
Both Breslow thickness and sentinel lymph node status were statistically significant in predicting cutaneous melanoma.
The FDA has approved a supplemental Biologics License Application to include a new dosing schedule for a nivolumab treatment as a 480 mg infusion given 4 weeks for a majority of its indications.
Researchers evaluated dermoscopic images of melanoma in situ and other flat pigmented skin tumors for the presence of predefined criteria.
While the primary treatment for melanoma is surgical excision, patients with metastatic disease require additional therapy; immunotherapy is an innovative class of medications accumulating data for use in this patient-group.
For men with metastatic melanoma treated with targeted or immune therapy, obesity is associated with improved survival.
Identifying risk of metastasis in patients with melanoma may help clinicians determine initial workup, referral patterns, and follow-up intervals.
The study findings suggest that a detailed dermatologic examination for melanoma may be reasonable in individuals <40 years of age with iris pigmented lesions.
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