Solid Organ Transplant, Diabetes Increase Risk for Cutaneous SCC After Mohs Surgery

Squamous cell carcinoma
Squamous cell carcinoma
Clinical factors such as history of solid organ transplantation, presence of diabetes, history of other malignancies, and poor histologic differentiation were significant risk factors for recurrence of cutaneous SCC in Asian patients treated with Mohs surgery.

High-risk factors for postsurgery recurrence of cutaneous squamous cell carcinoma (SCC) in patients treated with Mohs micrographic surgery (MMS) include history of solid organ transplantation, presence of diabetes, poor tumor differentiation, and history of cryotherapy at the site of disease, according to a study data published in the Journal of Dermatology.

The study was a retrospective analysis of patients with cutaneous SCC who were treated at a single dermatology clinic in South Korea between 2000 and 2017 (mean age, 72.8 years; n=237). Researchers reviewed electronic medical records as well as photographs taken prior to and after surgery. The study examined risk factors associated with recurrence of the tumor. Local recurrence was defined as recurrence of a tumor within 2 cm of the primary tumor.

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According to multivariate logistic and Cox regression analyses, risk factors for total recurrence and recurrence-free survival included having a history of solid organ transplantation (P =.034), presence of diabetes (P =.025), history of other malignancies (P =.017), and poor tumor differentiation (P =.019). The risk for local recurrence was increased in patients with a history of solid organ transplantation (P =.031) and cryotherapy history at the site of cutaneous SCC (P =.005). Additionally, distant metastasis was increased with poor differentiation of the tumor.

Limitations of the study included its retrospective design and the use of patient data from a single center.

Despite the limitations, the researchers suggest that their study “shows the results of a single surgical method under consistent clinical protocols in a single institution.”

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Oh Y, Kim J, Zheng Z, Kim S, Chung K, Roh M. Risk factors for recurrence in cutaneous squamous cell carcinoma after Mohs micrographic surgery: a retrospective review of 237 Asian patients [published online October 31, 2019]. J Dermatol. doi:10.1111/1346-8138.15129