PAK4 in Melanoma: Could This Target Extend Immunotherapy’s Reach?
Combining PD-1 blockade with PAK4 inhibitors could boost the number of patients helped by the therapy.
Skin Cancer
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1540-nm Nonablative Fractional Laser Safely Treats Actinic Keratosis
Investigators evaluated the therapeutic effect of a 1540-nm nonablative fractional laser on actinic keratosis, which can be treated by various treatment modalities.
Patients Underestimate Length of Mohs Surgery Scars
Scars from Mohs micrographic surgery (MMS) for facial skin cancers are often longer than patients expect.
Daylight Photodynamic Therapy as Effective as Conventional Blue Light Therapy for Actinic Keratosis
Not only is daylight photodynamic therapy as effective as conventional photodynamic therapy (using blue light) for the treatment of actinic keratosis but it is less painful, a novel study finds.
Findings from Meta-Analysis on Imiquimod Treatment for BCC Misleading
The purported benefits of imiquimod for the treatment of basal cell carcinoma are disputed in a critical review that finds numerous study flaws.
Large Decrease Seen in Melanoma Mortality From 2013 to 2016
From 2013 to 2016, there was a large decrease of 17.9 percent in melanoma mortality.
Weekday Vismodegib Dosing Better Tolerated in Treatment for Basal Cell Nevus Syndrome, BCC
A vismodegib regimen that includes a weekend drug holiday showed similar responses to treatment for patients with advanced basal cell carcinoma and basal cell nevus syndrome and provided a more tolerable adverse effect profile.
Should Predictive Markers, Adjuvant Therapies Be Focus for Merkel Cell Carcinoma Treatment?
Although there are a number of treatments for Merkel cell carcinoma, none offers impressive results. Research directed toward finding predictive markers for response, and adjuvant therapies, are warranted.
BRAF V600E Mutation is Prognostic Indicator for Cutaneous Melanoma
BRAF V600E mutation may indicate a reduced risk for relapse and/or metastasis in patients with melanoma.
Bereavement Tied to Higher Melanoma-Related Mortality
There is a decreased risk for melanoma diagnosis among bereaved individuals but increased mortality associated with melanoma compared with nonbereaved individuals.
Prevalence of Multiple Sunburns Rising, Despite Increases in Sun Protective Behaviors
Despite increases in most sun protective behaviors, the rates of primary and secondary skin preventive behaviors remain suboptimal, and the prevalence of multiple sunburns is rising.
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