Serum bilirubin and uric acid (UA) levels were significantly lower in patients with rosacea compared with healthy control participants, according to published findings in the Journal of Cosmetic Dermatology.

A study sought to evaluate oxidative stress levels in 87 patients with rosacea and 81 control patients who visited a dermatology outpatient clinic from December 2018 to July 2019. Women represented 73.6% and 72.8% of the rosacea and control groups, respectively. Average ages were 45.3 ± 14.6 years in the rosacea group and 44.2 ± 16.2 years in the control group. No statistical differences were found in the 2 groups in terms of gender or age (P > .05). For analysis of total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), and UA, blood samples were taken from all participants in antecubital vein after 8-hour fasting.

The results revealed that of rosacea type, 51.7% were erythematotelangiectatic, 43.7 % were papulopustular, and 4.6% were phymatous. Serum Tbil, Dbil, Ibil, and UA values were found to be significantly lower in patients with rosacea (all P < .001) compared with those of the control participants’ values. When evaluating the role of gender, men with rosacea were discovered to have lower Tbil, Dbil, Ibil, and UA levels compared with the men in the control group (P < .001, P = .003, P < .001, P = .024, respectively). Similar results were found for women: Tbil, Dbil, Ibil, and UA weresignificantly lower in the women with rosacea when compared with levels in the women in the control group (P = .005, P = .004, P = .007, P < .001, respectively). Within groups, the control participants’ Tbil, Ibil, and UA values were higher in men compared with women (P = .033, P = .022, P < .001, respectively).

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Limitations of the study include a small sample size and the analysis of patients from a single clinic.


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It may be useful to use bilirubin and UA or its precursors as replacement therapy in patients with rosacea who have low antioxidant status, the researcher concluded.

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Reference

Turkmen D. Serum bilirubin and uric acid antioxidant levels in rosacea patients (published online March 31, 2020). J Cosmet Dermatol. doi: 10.1111/jocd.13395