Oat Plantlet Cream Improves Redness and Soothes Rosacea

woman applying cream to face
woman applying cream to face
Results of 3 studies evaluating the effectiveness and tolerance of a facial skincare cream containing oat plantlet sap and mandarin extract in adults with rosacea are reported.

A facial skincare product containing oat plantlet sap and mandarin extract was found to be well tolerated and may be beneficial for the treatment of rosacea. These findings from a study published in Journal of the European Academy of Dermatology and Venereology.

This analysis reviewed data from 3 open-label, monocentric trials conducted from 2020 through 2021 in Poland and Romania. Patients (N=107) with rosacea were evaluated at baseline and after 21and 28 days of applying the cream twice daily. The cream contained about 73% water, 20% organic oat sap, 4% mandarin extract containing emollients, hydrating agents, and emulsifiers, 1.5% texturing agents and less than 1% preservatives. Participants in the second study also underwent potassium titanyl phosphate laser or intense pulsed light therapy. Safety, tolerability, and efficacy were evaluated.

Studies 1 (n=33), 2 (n=30), and 3 (n=44) comprised 97%, 100%, and 84% women who had a mean age of 54±1, 43±2, and 50±2 years. Also, 47%, 30%, and 48% of participants had dry facial skin, respectively.

Overall, 14% of patients had a cutaneous reaction, presenting with functional signs (8%), physical signs (4%), or both functional and physical signs (2%). The reactions were likely or very likely related with the experimental cream (n=12), it was noted. A participant withdrew due to the reaction, and 1 modified their application regimen.

In study 1, burning sensations decreased by 28% (P <.001), global flush severity score by 41% (P<.001), transepidermal water loss by 11% (P <.001), skin pH increased by 2.6% (P <.001), skin tightness decreased by 66% (P <.05), clinical erythema assessment scores by 8% (P <.05), and intensity of discomfort by 35% (P <.05). According to the investigator’s grading, 63% of participants had a slight improvement and 28% a marked improvement.

In studies 2 and 3, efficacy was based on subjective evaluations. Participants who underwent a superficial dermatological procedure or had papulopustular rosacea reported a reduction in redness (83% and 93%) and soothing effects (97% and 88%), respectively. Participants indicated they were satisfied with the topical (93%) and 76% to 85% said they would be willing to buy the cream.

The major limitations for this analysis were the lack of a comparator group in the studies and the subjective efficacy outcomes in studies 2 and 3.

The study authors concluded that this topical cream containing oat plantlet sap and mandarin extract facilitated an improvement in redness and soothed discomfort among patients with rosacea.

Disclosure: Several authors declared affiliations with industry. Please refer to the original article for a full list of disclosures.


Fabbrocini G, Monteil CB, Carballido F. A cream containing the sap of oat plantlets and mandarin extract soothes the symptoms of rosacea and improves the quality of life of patients. J Eur Acad Dermatol Venereol. 2022;36 Suppl 8:3-11. doi:10.1111/jdv.18201