Real-world use of calcipotriol (50 μg/g) plus betamethasone dipropionate (0.5 mg/g) (Cal/BD) aerosol foam formulation markedly improves scalp psoriasis and provides relief from itching, according to case study results published in Clinical, Cosmetic and Investigational Dermatology.

The researchers aimed to explore real-world efficacy and satisfaction with a recently developed Cal/BD aerosol foam formulation that allows for enhanced skin penetration and absorption in 3 patients with scalp psoriasis.

The first patient was a 29-year-old woman who presented with refractory scalp psoriasis with a Psoriasis Area and Severity Index (PASI) of 11.4. Marked psoriasis was visible with infiltrating deposits of scaly skin, as well as psoriasis capitis with plaques of scales along the hairline and behind the ears. For 4 weeks, the patient applied Cal/BD aerosol foam once daily in the evening and washed it out the next day. After 4 days of treatment, reduced itching was reported. After the full 4 weeks of treatment, her PASI score had decreased to 1.6.

The second patient was a 71-year-old woman with refractory scale psoriasis, with pronounced psoriasis capitis and infiltrates of adhering flaky plaques on the scalp and hairline, as well as behind the ears. Reduced itching was similarly reported after 4 days of treatment, and after the full 4 weeks her PASI score was reduced from 4.8 to 0.3. Despite despondence at her initial consultation, the patient reported she was very satisfied with treatment.


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The third patient was a 33-year-old man with marked plaque psoriasis visible on his trunk, extremities, and scalp. Approximately 20% of his body surface area was affected, including more than 50% of his scalp surface. His starting PASI score was 15 and his Dermatology Life Quality Index score was 24. After 4 weeks of treatment, partial skin clearance was achieved on the patient’s trunk and extremities (18% of body surface area affected) with almost complete clearance on his scalp. His PASI score was reduced to 10 and the Dermatology Life Quality Index Score improved to 14. The patient reported very good satisfaction with the efficacy and use of the product.

“Based on the cases reported herein, Cal/BD aerosol foam provided effective therapy for scalp psoriasis in adults, including cases which were resistant to previous treatment,” the researchers concluded. “Use of Cal/BD aerosol foam for the recommended 4 weeks was associated with visible improvements in scalp psoriasis, and patients reported marked relief from itching and satisfaction with treatment.”

Disclosure: Multiple authors reported funding from the pharmaceutical industry. Please see the original reference for a full list of author disclosures.

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Reference

Anderko M, Navarro Triviño FJ, Sharples CL. Calcipotriol plus betamethasone dipropionate aerosol foam for scalp psoriasis. Clin Cosmet Investig Dermatol. 2019;12:699-705. doi:10.2147/CCID.S221078