Psoriasis

PSORIASIS

FEATURE ARTICLE

Psoriasis in Older Adults: A Treatment Challenge for Clinicians

Colby Stong

Daniel C Butler, MD, co-director of the Geriatric Dermatology Clinic at the University of California, San Francisco, and Afsaneh Alavi, MD, a dermatologist at the Mayo Clinic in Rochester, Minnesota, share their insights on treating older adult patients with psoriasis.

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Apremilast Under Review for Mild to Moderate Plaque Psoriasis

Brian Park, PharmD

The sNDA is supported by data from the multicenter, double-blind, placebo-controlled phase 3 ADVANCE trial.

Psoriasis is a chronic disease that affects 2% to 3% of men and women.2 The disease is characterized by plaques and reddish scaly patches. Some women develop pustular psoriasis, which can be life-threatening if severe.3 Although most women with psoriasis notice symptom improvement during pregnancy, 10% to 20% have symptom deterioration.3 The effect of psoriasis on fetal health is unclear.2 Some studies have suggested that psoriasis, which is a TH1-driven disease, contributes to lower birth weight as observed in other TH1-driven diseases.2 The proposed negative effects of psoriasis on fetal health are usually linked to moderate or severe psoriasis. Topical corticosteroids are safe to use during pregnancy, but topical tar products, tazarotene, and retinoids are teratogenic and should be avoided.2,7 Ultraviolent B phototherapy is safe in pregnant women with moderate to severe psoriasis but may compromise folate levels.2 Limited data are available about the safety of biologics during pregnancy, and careful consideration is required before prescribing.2,7

Bimekizumab Tops Secukinumab for Plaque Psoriasis

For patients with moderate-to-severe plaque psoriasis, bimekizumab is noninferior and superior to secukinumab and adalimumab.

Experiences with Stigma Among Patients with Psoriasis

Emily Pond

The prevalence and predictors of stigmatizing attitudes that patients with psoriasis anticipate and experience was investigated.

Psoriasis Incidence in the United States Remains Steady

Psoriasis incidence in the United States is steady, but increases with age and is higher among Whites.

Pain Alone Does Not Confer Premature Mortality in Psoriatic Arthritis Patients

Lauren Biscaldi

The researchers investigated whether higher cumulative pain intensity is associated with an excess mortality risk in patients with psoriatic arthritis.

Immunosuppressive and Biologic Therapy in Expectant Fathers With IMIDs Not Linked to Adverse Birth Outcomes

Colby Stong

Researchers examined the safety of exposure to immunosuppressive or biologic agents around the time of conception in expectant fathers with IMIDs.

Higher levels of alcohol and tobacco use put men at risk for liver disease, such as cirrhosis and alcoholic liver disease. Men who have sex with men are at increased risk for viral hepatitis B, and should be screened accordingly.

Does Methotrexate Confer a Higher Risk for Liver Disease in Patients With Psoriasis?

Brandon May

Liver disease risk for patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis treated with methotrexate were compared.

Is There an Association Between Psoriasis and Thyroid Disease?

Brandon May

Aside from autoimmunity, an analysis of the tie between psoriasis and thyroid diseases is provided.

Black Patients, Psoriasis, and Biologic Agents

Brandon May

Rates of biologic agent use in minority patients with psoriasis compared with White patients were determined in this study.

For Psoriasis, Risankizumab Has Best Long-Term Risk-Benefit Profile

Brandon May

The short-term and long-term safety and benefit-risk profiles of drugs used to treat moderate to severe psoriasis were compared.

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