The use of a natural ingredient–based moisturizing cream for the treatment of very dry skin delivers benefits comparable to those seen with a colloidal oatmeal–containing benchmark product, according to study results published in the Journal of Drugs in Dermatology.
a total of 32 participants completed the study. Following a 5-day washout period, all participants used the natural ingredient–based moisturizing cream and oatmeal-containing cream on randomly assigned legs twice daily for 3 weeks. For the next 2 weeks, the participants did not use any moisturizer on their legs for the following 2 weeks.
Skin moisture assessments demonstrated a statistically significant increase in hydration with both products at all time points during the treatment phase of the study (18.26.1 arbitrary units [AU] with the test product vs 19.3±6.8 AU with the benchmark product; P =.083). Moreover, both moisturizing products decreased transepidermal water loss measurements during the treatment phase of the study (mean, 3.8±1.4 g x m2 x h1 vs
3.8±1.4 g x m2 x h1, respectively; P =.977), thus demonstrating their ability to improve stratum corneum barrier function.
Per clinical assessment, both moisturizers significantly reduced visual dryness (median, 2.75 vs 3, respectively; P =.649) and tactile roughness (2.5 vs 2.5, respectively; P =.646) during the treatment phase. Improvements in clinical parameters evaluated persisted even after treatment cessation.
The investigators concluded that no significant difference was found overall between the 2 products tested over the course of the study. Both moisturizers were associated with significant improvements in stratum corneum hydration and barrier function, which persisted during regression.
Gunt HB, Levy SB, Lutrario CA. Clinical improvements in very dry skin from a natural ingredient-based moisturizing cream compared with a leading colloidal oatmeal control. J Drugs Dermatol. 2018;17(7):758-764.