A combination of high-concentration minoxidil and carboxygas can increase the level of hair growth in patients with androgenetic alopecia (AGA), according to study results published in the Journal of Cosmetic Dermatology.

In this study, researchers investigated a novel combination therapeutic approach (high concentration of minoxidil and carboxygas) using a needling tactic to increase the rate of hair growth. At the Jordan Clinic, Tehran University of Medical Sciences, in Tehran, Iran, investigators treated 9 adults with AGA (age range, 25to 55 years; 5 women) with carboxytherapy mediated by needling immediately followed with minoxidil (20%) by microneedling in the same area.  Patients were treated once a month for a total of 4 sessions, and hair density measurements and diameter by trichograms were recorded before and after treatment. Hair growth was assessed using the pull test. To assure the authenticity of the results, researchers took pictures before and 3 months after the final treatment.

The results revealed that hair density significantly increased after treatment in both men and women, and, more specifically, hair density in women significantly improved compared with men. Hair diameter also increased significantly in all patients after treatment 1 and especially 3 months after final treatment (91.9±2.3 μ and 77±2.1 μ vs 53.2±2.5 μ for 1 and 3 months after treatment vs before treatment in women and 74.5±2.1 μ and 57.5±1.7 μ vs 46.5±2 μ for 1 and 3 months after treatment vs before treatment in men). As with hair density, hair diameter in women was significantly improved compared with men. The pull test demonstrated a significant decrease in the number of extracted hair after combination therapy.  Researchers observed no differences between men and women in regards to the pull test.


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A limitation of the study is the small sample size and the use of a single clinic to evaluate the treatment strategy.

The researchers concluded that their results suggest that “combination therapy using needling is a well-tolerated therapy in [AGA] patients over long periods considering the less possible side effect.”

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Reference

Nilforooshzadeh, Lofti E, Heidari-Kharaji M, Zolghadr S, Mansouri P. Effective combination therapy with high concentration of minoxidil and carboxygas in resistant Androgenetic alopecia: Report of nine cases [published online March 12]. J Cosmet Dermatol. doi:10.1111/jocd.13362