Silicone-Based Scar Cream Effective in Upper Eyelid Blepharoplasty

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Investigators sought to determine whether a silicone-based topical scar cream that incorporates selective growth factors can help lower the frequency of postoperative cicatricial and hypertrophic changes in upper eyelid blepharoplasty incisions.

Persons undergoing upper eyelid blepharoplasty incisions may benefit from the early use of a silicone-based scar cream, according to recent study results published in the Journal of Drugs and Dermatology. A silicone-based cream can reduce cicatricial and hypertrophic scarring.

This single-surgeon, retrospective study included 272 eyelids, 132 of which did not receive treatment after cosmetic upper eyelid blepharoplasty and 140 of which received SKN2017B, a silicone-based scarring cream with selective growth factor. Persons treated with SKN2017B applied the cream 2×/d for 3 months. The researchers compared the 2 groups for incidence of triamcinolone/5-fluorouracil (5-FU) injections into areas of hypertrophic and cicatricial changes using a version of the Vancouver Scar Study Scale. They used a Student’s t-test to perform statistical analysis.

Investigators administered intralesional triamcinolone/5-FU injections to 43.9% of eyelids that were not treated with SKN2017B but gave injections to only 22.9% of treated eyelids (P <.05). They reported no adverse reactions in either cohort. Researchers administered 113 intralesional injections (73.5% by 1 month, 17.7% by 2 months, 4.4% by 3 months, 3.5% by 5 months, and 0.9% by 6 months) in the 6-month follow-up period. All participants achieved grade ≥1 on the Vancouver Scar Study Scale’s pliability and height metrics.

Limitations to this study included variance of intralesional wound modulation between surgeons, as well as a lack of assessment of other scarring-related issues and suture type.

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The study researchers concluded that “surgeons that pay particular attention to the quality of scars may benefit from using a silicone cream based scar cream that has proven effective in wound healing. Furthermore, patients that are not able to follow-up as frequently as desired due to various situations (long-distance travel, employment reasons) may benefit from a topical scar cream that can reduce the likelihood of post incisional cicatricial or hypertrophic changes.”

Zoumalan is associated with Allergan, Inc. and owns stock in the company producing this study’s scar cream.

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Kalasho BD, Kikuchi R, Zoumalan CI. Silicone-based scar cream for post upper eyelid blepharoplasty-associated cicatricial and hypertrophic scarring. J Drugs Dermatol. 2019;18(5):440-446.