Platelet-rich plasma (PRP) using a digital centrifuge with large sodium citrate tubes on a centrifuge speed of 900 rpm has demonstrated efficacy and safety in female pattern hair loss (FPHL) therapy, according to study findings published in the Journal of Cosmetic Dermatology.

This comparative study included 40 women (20 to 35 years of age; grade I and II Ludwig classification; serum ferritin ≥70 μg/mL) with FPHL recruited from Al-Zahraa University Hospital in Cairo, Egypt. Participants were randomly assigned to 4 groups (each group n=10), with each group receiving 3 monthly intradermal PRP injections. The groups were stratified by number of spins and speed/type of centrifuge, as well as PRP tube size. Clinical trichoscan evaluation was performed on all participants before PRP sessions and 1 month after the final session. Terminal and vellus hair counts as well as average hair width were recorded.

Platelet count increased significantly in group IV (digital centrifuge, large-sized sodium citrate tube, low centrifuge speed of 900 rpm) compared with the other 3 groups (P <.001). However, post-treatment trichoscan revealed no statistically significant difference between groups in terms of percentage of terminal or vellus hair, terminal:vellus ratio, or average hair width. A positive association was observed between the percent change in platelet count and both terminal hair (P =.004) and terminal:vellus ratio (P <.001).


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Limitations to this study include a lack of assessment of platelet function, morphology, and growth factors.  Lack of a control group and a short follow-up were also cited.

The study researchers conclude “using digital centrifuge, larger sodium citrate tubes (9 ml compared to 2 ml tube) and a single spin with low centrifugation speed (900 rpm) for 10 min is ideal for PRP preparation.” They also call for “large-scale, controlled, and randomized studies to confirm [their] initial encouraging results and recommend adding PRP maintenance sessions with more prolonged follow-up period.”

Reference

Moftah NH, Taha NE, Alhabibi AM, Hamdino M. Different platelet-rich plasma preparation protocols in Female pattern hair loss: does it affect the outcome? A pilot study Published online January 2, 2022. J Cosmet Dermatol. doi:10.1111/jocd.14648