Growth factor-induced therapy resulted in skin rejuvenation in women of multiple races with 95% confidence, according to study findings published in the Journal of Cosmetic Dermatology.

Investigators examined the efficacy of 2 sessions of growth factor-induced therapy using AQ Skin Solutions, which contains a mixture of transforming growth factor beta (TGF-β), granulocyte-monocyte colony-stimulating factor, and platelet-derived growth factor. The procedures were to address anti-aging and promote skin rejuvenation.

The pilot study included 30 women (20 Asian, 5 White, and 5 Latina) with an average age of 38 years. The women had mild to moderate signs of skin aging, including fine lines and wrinkles, and their primary goal was to rejuvenate and improve their overall skin appearance.

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Clinical assessment, VISIA® photography, and independent assessment of before and after photographs were performed by 2 clinicians and 2 laypersons. Participants used the FACE-Q questionnaire to score changes about their skin texture, radiance, pore size, wrinkles, pigmentation, tightness, and overall skin appearance.

A total of 27 women completed 2 sessions at a 2-week interval. The global assessment demonstrated that the treatment improves the skin and helps rejuvenation in women of multiple races (95% confidence) with an average of +1.40 and standard deviation (SD) of 0.72. Within 6 weeks, the assessment improvement scores increased to an average of +1.64 with an SD of 0.71 for White and Latina participants (98% confidence).

The most common improvements according to the participants were “reduction of pigmentation or brightening of the skin or radiance” (24 comments), “lifting or tightening of the skin” (23 comments), and “wrinkle reduction” (6 comments). The women reported extremely high satisfaction with their treatment outcome (average of 72 with an SD of 18) in their completed FACE-Q questionnaires.

Study limitations include the small number of participants, relatively few ethnicities, and a short follow-up.

“Use of micro-needling and growth factors over 6 weeks and provision of 2 treatments at 2-week intervals revealed improvement in overall skin appearance, brightness, skin texture, and tightness,” the study authors commented. “The procedure is noninvasive, safe, with no or minimal downtime, and resulted in high participant satisfaction. These results may not be replicable using other growth factor serums.”

Disclosures: One of the authors reported affiliations with the pharmaceutical industry. Please see the original reference for a full list of disclosures.


Samizadeh S, Belhaouari L. Effectiveness of growth factor-induced therapy for skin rejuvenation: a case series. Published online October 6, 2020. J Cosmet Dermatol. doi:10.1111/jocd.13750