HealthDay News — Hyaluronic acid gel fillers of the periorbital region are well tolerated over 5 years of follow-up, according to a study published online in the Journal of Cosmetic Dermatology.

Hamzah Mustak, FCOphth, from the University of Cape Town in South Africa, and colleagues conducted a long-term follow-up review of complications associated with periocular injection of hyaluronic acid gel fillers. A total of 147 patients had at least 5 years of follow-up since their first injection.

In long-term follow-up, the researchers found that malar edema (11%), blue-gray dyschromia (31.3%), and contour irregularities (30.5%) continued to be the most common adverse effects; however, most of these complications (90%) were mild and no intervention was required. The investigators noted no significant association between the mean volumes injected and severity grading of each complication.

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“Conservative treatment and tailored treatment approaches, in terms of volume and frequency of injections, may decrease the tendency of these adverse effects to occur,” the authors write.

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Mustak H, Fiaschetti D, Goldberg RA. Filling the periorbital hollows with hyaluronic acid gel: long-term review of outcomes and complications [published online November 11, 2017]. J Cos Dermatol. doi: 10.1111/jocd.12452