Hidradenitis suppurativa (HS) is strongly associated with schizophrenia, according to study findings published in the Journal of the European Academy of Dermatology and Venereology.

Researchers investigated the association between HS and schizophrenia in a population-based study in Israel. They compared patients diagnosed with HS (n=4191) with age- and sex-matched control participants (n=20,941) and evaluated the association via multivariate binary logistic regression, adjusting for smoking status and demographic factors.

The findings revealed that schizophrenia was 10 times more prevalent in patients with HS compared with control participants (1.4% and 0.4%, respectively, P <.001). When stratified for age, HS patients had increased prevalence of schizophrenia when compared with control participants in the 30- to 69-year-old age group. Furthermore, prevalence in the 30- to 49-year-old age group increased 3-fold, and prevalence in the 50- to 69-year-old age group rose 4-fold compared with control participants. In addition, multivariate analysis demonstrated that HS was discovered to be associated with schizophrenia (odds ratio 1.44; 95% CI, 1.01-2.07, P <.05).

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A commentary on the research concluded that screening for severe mental illness during the assessment of patients with HS is crucial, as comorbid psychiatric disorders may affect outcomes and a psychodermatology consolation may be warranted.


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References

1.  Bitan DT, Berzin D, Cohen AD. Hidradenitis suppurativa and schizophrenia: a nationwide cohort study. J Eur Acad Dermatol Venereol. 2020;34:574-579.

2. Poot F. Psychiatric diseases from the psychotic spectrum in hidradenitis suppurative patients: an under-recognized comorbidity. J Eur Acad Dermatol Venereol. 2020;34(3):442-443.