FDA: E-Liquids Found to Contain Undeclared Prescription Drugs

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Sildenafil and tadalafil can interact with nitrates found in some prescription drugs, such as nitroglycerin, and may lower blood pressure to dangerous levels.

CDC: Top 10 Drugs Involved in Drug Overdose Deaths

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Using data from the 2011 to 2016 National Vital Statistics System-Mortality files, the authors conducted a literal text analysis of death certificates to identify drugs mentioned as contributing to the cause of overdose death.

Diagnostic Challenges of Neutrophilic Dermatosis May Lead to Misdiagnosis

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Clinical morphologic testing in addition to tissue biopsy and culture are critical in distinguishing NND from NF and treating appropriately.

Overcoming the Barriers to Including Pregnant Women in Clinical Trials

By Emily Pond

Pregnant women are considered a "vulnerable" population in the eyes of clinical researchers.

EMS Times Longer for Patients From Poorest Neighborhoods

Patients with cardiac arrest from the poorest neighborhoods have longer emergency medical service (EMS) times.

DRESS May Be Mitigated by Slower Titration Rates of Cenobamate

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Investigators examined whether a reduction in titration rates utilized in earlier trials would reduce the incidence of DRESS in patients taking cenobamate.

Many Americans Unaware of Promise of Personalized Medicine

Medical science has made tremendous advances in personalized medicine. However, the American public is still struggling to understand the implications of these targeted treatments.

Skin Autofluorescence Predicts T2D, Heart Disease, Mortality

Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease (CVD), and mortality in the general population.

Multispectral Optoacoustic Tomography to Assess Vascular Malformations

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Multispectral optoacoustic tomography may become a promising and versatile tool for noninvasive diagnosis and monitoring of vascular malformations before and after treatment.

Adjunctive Dapsone Therapy Effective for Pyoderma Gangrenosum

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The use of dapsone may be effective as adjunctive therapy for patients with pyoderma gangrenosum.

Lanadelumab Well-Tolerated in Hereditary Angioedema

By Bryant Moeller

Patients with hereditary angioedema who received lanadelumab exhibited few cases of hypersensitivity and had low immunogenicity.

Cetirizine Provides More Benefits for Acute Urticaria Than Diphenhydramine

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The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.

Consensus on Global Assessment Quality Measure for Inflammatory Skin Disorders

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The members reached consensus on the use of a 5-point ordinal scale with descriptors provided via referenced electronic platforms.

Vitiligo Linked to Mental Health Disorders

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Study results suggest that vitiligo is associated with an increase in primary hospitalizations for several mental health conditions.

Treatment of Refractory Diabetic Foot Ulcers Improved With LeucoPatch

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The primary study outcome was the proportion of ulcers that healed within 20 weeks evaluated in the intention-to-treat population.

Dermatologic Adverse Events Common With Targeted Therapies, Immunotherapies

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"Closer collaboration between dermatologists and oncologists is essential," write the authors.

Weak Evidence for Increased Prevalence of Bullous Pemphigoid Among Cancer Patients

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Higher incidence rates of subsequent BP have been reported in patients with brain and nervous system tumors than in those with other forms of cancer.

Socioeconomic, Demographic Characteristics Influence Access, Use of Dermatology Outpatient Care

There is an urgent need to characterize these differences further to improve rates of outpatient dermatologic care use in disadvantaged populations.

Quantity of Opioids Prescribed Postop Linked to Consumption

The quantity of opioids prescribed after surgery is associated with patient-reported opioid consumption.

Scoring System May Help Screen High-Risk Patients for Cytomegalovirus Disease, Complications

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Investigators sought to determine a scoring system for DiHS/DRESS that may be used to monitor severity and stratify risk for developing CMV disease and complications.

Trichloroacetic Acid Promising for the Treatment of Persistent Oral Mucosal Lesions in Pemphigus Vulgaris

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The use of topical trichloroacetic acid 33% as treatment for persistent old refractory oral mucosal lesions in patients with pemphigus vulgaris (PV) may be promising.

Low-Dose Ruxolitinib May Promote Hair Regrowth in Severe Alopecia

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Complete or near-complete hair regrowth occurred in 5 patients, with a 98% improvement in the Severity of Alopecia Tool score.

Updated Guidelines Released for Emergency Care of Children

The American Academy of Pediatrics, American College of Emergency Physicians, and Emergency Nurses Association have released updated guidelines for emergency care of injured and critically ill children.

Maternal Age, BMI Among Prenatal Risk Factors Linked to Infant Hemangiomas

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Researchers reviewed the charts of 869 mothers and infants —in cases where infants were diagnosed with IH — between January 1, 1976 and December 31, 2010.

FDA-Approved Test Provides Pharmacogenetic Reports Directly to Consumers

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The 23andMe Personal Genome Service Pharmacogenetic Reports test can detect 33 variants for multiple genes, corresponding to more than 50 commonly prescribed medications and over-the-counter products.

Oral Dexamethasone May Help Stop or Slow Disease Progression in Non-Segmental Vitiligo

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The 2-year retrospective study investigated participants with active non-segmental vitiligo.

Most Supplements Contain Prohibited Stimulants

Many supplements contain one or more stimulants that have been the subject of U.S. Food and Drug Administration-issued public notices.

Variability in Geographic Availability of New Antibiotics

There is considerable variability in the geographic availability of antibiotics.

Light Use of Topical Skin Tx Before Radiotherapy Seems Safe

Contrary to the advice most cancer patients receive, light or moderate use of topical agents before radiation treatment does not appear to increase the radiation dose to the skin.

Disease Extent, Nail Involvement May Predict Clinical Outcomes of Contact Immunotherapy for Alopecia Areata

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Hair growth outcomes with contact immunotherapy for alopecia areata were associated with many factors and there was a significant variability in the criteria used.

Clostridium difficile Spores Survive Laundering of Sheets

Clostridium difficile spores are able to survive laundering through a commercial washer extractor.

Personal Care Products: What Patients Should Know About Shaving, Detergents, and More

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Detergents labeled as dye- and fragrance-free may be the best option for certain patients.

Treatment for WHIM Syndrome Gets Orphan Drug Designation

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X4 Pharmaceuticals is developing the drug, which is currently in a Phase 2/3 clinical trial involving patients with WHIM syndrome.

Topical Cantharidin Safe and Effective for Warts and Molluscum Contagiosum

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Topical cantharidin showed high efficacy and safety for the treatment of warts, especially when used with podophyllotoxin and salicylic acid.

Treating Chronic Itch: Therapeutic Review

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Itch is "learned" in the nervous system, said Dr Berger, with involvement by both central and peripheral neural processes.

Solutions for Hyperhidrosis: Newly Approved Treatments and Research Update

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Newly approved treatment options for axillary hyperhidrosis give more opportunities for clinicians to provide personalized treatment for patients.

Topical Liposomal Hydroquinone vs Conventional Treatments for Melasma: Which Is Better?

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Liposomal hydroquinone has a significant therapeutic effect in patients with melisma but is not superior to conventional treatments.

Dermatoscopic Magnets Present No Safety Risk for Patients With CV-Implanted Electronic Devices

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The safety risk of dermatoscope magnets in patients with cardiovascular implanted electronic devices was examined.

Active Pharmaceuticals ID'd in >700 Dietary Supplements

Dietary supplements often include active pharmaceuticals, even after warnings from the U.S. Food and Drug Administration.

Natural Products Superior to Synthetic, Dermatologist-Recommended Products for Sensitive Skin

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The one area where synthetic products outperformed nature-based products was in hydration.

Estimates of Pemphigoid Prevalence in the United States Based on Age and Gender

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Women 60 and older comprise the majority of cases of pemphigoid in the United States.

Nitric Oxide-Releasing Hydrogel SB208 Effective for Treating Tinea Pedis

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SB208, a stable was shown to be well-tolerated and effective for the treatment of interdigital tinea pedis.

Accepted Manuscripts Meet More Criteria for Research Reporting

Accepted manuscripts for observational studies have better adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist compared with rejected manuscripts.

Homocysteine, Folate, Vitamin B12 as Potential Biomarkers for Vitiligo

Investigators examined the role of serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo.

The Open Access Debate: Should Patients Freely Access Research?

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Patients and their families are advocating for their right to access the latest medical research papers to help find potential treatments and understand health conditions.

Recognizing Skin Popping Scars and the Benefits of Early Intervention

By Dermatology Advisor Contributing Writer

The case study underscores the significance of recognizing lesions associated with skin popping.

FDA Issues Safety Communication Regarding Pen Needle Use

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Standard pen needles have an outer cover and removable inner needle cover, while safety pen needles have an outer cover and a fixed inner needle shield that is not removed before an injection.

Qbrexza Now Available for the Treatment of Primary Axillary Hyperhidrosis

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A single cloth should be used to apply Qbrexza to both underarms.

FDA Requests Another Clinical Trial for Ruconest in HAE Prophylaxis

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The Company filed the sBLA last November following FDA feedback on two completed Phase 2 trials of Ruconest for prophylaxis of HAE attacks.

Dozens of Medical Groups Join Forces to Improve Diagnoses

Every nine minutes, a patient in a U.S. hospital dies because a diagnosis was wrong or delayed -- resulting in 80,000 deaths a year.

Importance of Screening Skin Pigmentation Disorders in Systemic Sclerosis

By Dermatology Advisor Contributing Writer

Investigators examine the association between pigmentation disorders and systemic involvement in patients with systemic sclerosis.

Mental Health Hospitalizations in Patients With Alopecia Areata

Patients with alopecia areata may have multiple risk factors for mental health disorders, including psychological distress and impaired quality of life.

Bullous Pemphigoid Risk in Patients With Diabetes Treated With DPP-4 Inhibitors

By Dermatology Advisor Contributing Writer

The association between DPP-4 inhibitor use and the risk for developing bullous pemphigoid was examined.

Scar Improvement Enhanced With Intralesional Triamcinolone Acetonide Injection During Static Stage

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The current study provides new clinical evidence for the optimization of drug therapy for pathologic scars.

Incorporating Guidelines Into Clinical Practice: An Interview With Gary L. LeRoy, MD

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Despite their advantages, many clinicians do not necessarily agree with the centrality or content of CPGs. Others — especially primary care physicians (PCPs) — are overwhelmed by the vast and ever-increasing numbers of guidelines issued by multiple societies.

Prurigo Nodularis More Likely in African-Americans

African-American patients are more likely to have prurigo nodularis, which is associated with systemic, cardiovascular, and psychiatric comorbidities.

Glycopyrronium Tosylate Effective for Reducing Primary Axillary Hyperhidrosis

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Topical once-daily glycopyrronium tosylate appears to provide a noninvasive, well-tolerated treatment option for patients with primary axillary hyperhidrosis.

Data Age in Clinical Trials Is About Three Years at Publication

The median data age in clinical trials in journals with a high impact factor is about three years at publication.

Novel Treatment for Pemphigus Granted Orphan Drug Designation

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Preliminary results from a Phase 1b proof-of-concept study showed that SYNT001 was associated with clinical improvement (as measured by Pemphigus Disease Area Index score) and induced a rapid reduction in lgG and circulating immune complex levels.

Gender Minorities Less Engaged in Health-Promoting Behaviors

Lesbian and bisexual women and transgender adults have lower participation in health-related behaviors than heterosexual men and women.

Docs, Consumers Agree on Benefits of Virtual Care

Physicians and consumers agree on the benefits of virtual care, but physician adoption of virtual care technologies is low.

Oral JAK3 Inhibitor Granted Breakthrough Tx Designation for Alopecia Areata

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PF-06651600 is an investigational oral Janus kinase 3 (JAK3) inhibitor that is being evaluated in a Phase 2 study which will assess the treatment based on changes from baseline in Severity of Alopecia Tool (SALT) score.

Gene Therapy for Localized Scleroderma Gets FDA's Fast Track Designation

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Clinical enrollment for an open-label, single-arm Phase 1/2 trial of FCX-013 was initiated in August 2018.

Publication Characteristics Tied to Treatment Effects

Published trials have larger treatment effects than unpublished trials, while trials published in a language other than English have larger treatment effects versus those published in English.

Transcutaneous Pneumatic Injection More Effective, Less Painful for Lichen Simplex Chronicus Treatment

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Since the amount injected and the air pressure can be set on the TPI device, the same amount of drug is delivered at the same depth to every injection site.

Pediatric Vitiligo: Look Beyond the Skin for Complete Treatment

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What is commonly thought of as a superficial skin disease may have autoimmune etiology that deserves to be examined further.

Poor, Non-English Speaking Cancer Patients Need Support

There are steps health care providers can take to better support cancer patients who do not speak English, are underinsured, and may face other major financial challenges.

Natural Ingredient-Based Moisturizer Comparable to Oatmeal-Based Product for Very Dry Skin

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All participants used the natural ingredient-based moisturizing cream and oatmeal-containing cream on randomly assigned legs twice daily for 3 weeks.

Many ED Visits for Antibiotic Adverse Drug Events in Children

Emergency department visits for antibiotic adverse drug events in children account for 46.2 percent of emergency department visits for ADEs resulting from systemic medication.

High-Intensity Radiofrequency Microneedling Device Effective for Hyperhidrosis

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The HIFRF device offers versatility to patients who have been seeking a treatment option for PAH.

Artificial Intelligence Holds Promise in Medicine

Artificial intelligence in health care offers opportunities for early detection and triage, diagnostics and personalized medicine, and medical decision-making.

First-of-its-Kind Therapy Approved to Prevent Hereditary Angioedema Attacks

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The approval was based on data from 4 clinical trials, including the 26-week Phase 3 HELP (Hereditary Angioedema Long-Term Prophylaxis) study that enrolled 125 patients with HAE aged ≥12 years.

Single-Administration Treatment for Hereditary Angioedema Gets Orphan Drug Status

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ADVM-053 is being developed as a single‑administration treatment that could potentially provide sustained levels of the C1 esterase inhibitor protein, which may prevent breakthrough angioedema attacks.

Decline in Hospital-Acquired Conditions Continues

The rate of hospital-acquired conditions continued its decline from 2014 to 2016.

Improved Quality of Life in Adolescents With Acne After Educational Initiative

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The researchers theorized that education aimed at adolescents and delivered in a socially normalized group setting would be associated with durable QoL improvements.

Most Surgical Residents Want Financial Education

Surgical residents feel strongly that personal financial education should be offered during medical training.

Advanced Practice Professionals Performing More Dermatologic Procedures

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The most common procedures that APPs performed in 2015 were destructions of benign neoplasms, biopsies, and destructions of malignant neoplasms.

Similar Outcomes for Rural, Urban Cancer Patients in SWOG Trials

Rural and urban cancer patients with uniform care access through participation in a SWOG treatment trial have similar outcomes.

Doctors Often Not Discussing Risk Factors With Patients

Patients report that doctors are routinely not discussing known risk factors for common causes of death.

Factors Associated With Relapse, Prognosis in Cutaneous Polyarteritis Nodosa Identified

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The presence of pretreatment cutaneous ulcer was significantly associated with relapse between the 2 groups.

Omalizumab Safe, Effective for Antihistamine-Resistant Chronic Spontaneous Urticaria

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Study assessments included the urticarial control test (UCT), the 7-day urticaria activity score (UAS7), angioedema activity score, and D-dimer levels.

Gene Therapy Gets Orphan Drug Designation for Severe Genetic Skin Disease

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Patients with TGM-1 deficiency may have chronic pronounced scaling of the skin with increased transepidermal water loss, as the TGM-1 enzyme is essential for facilitating the formation of the epidermal barrier, which prevents dehydration.

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

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Recurrence of GA following cancer treatment should signal the possibility of cancer recurrence.

Skin Appears to Be Key Pathway for Absorption of BBQ Fumes

Dermal absorption is a more important pathway than inhalation for the intake of low-molecular-weight polycyclic aromatic hydrocarbons during barbecuing.

National Guideline Clearinghouse Offline Due to Funding Cuts

The mission of the NGC was to offer a source of objective, detailed information on clinical practice guidelines, and to further their dissemination, implementation, and use by health care professionals.

Several Invasive Procedures Linked to Infective Endocarditis

Several invasive medical procedures, including cardiovascular procedures and procedures of the skin and management of wounds, are associated with increased risk of infective endocarditis.

Teen Boy Suffers Serious Burns After 'Hot Water Challenge'

An Indianapolis teen suffered serious burns after his friends poured boiling hot water on him as part of fad called the "Hot Water Challenge."

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

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The risk for depression was increased significantly in patients with systemic lupus erythematosus and cutaneous lupus erythematosus.

The Association Between Skin Diseases and Metabolic Syndrome

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Investigators examine the association between various skin conditions and metabolic syndrome.

HerbList App Launched to Provide Information on Herbal Products

The National Institutes of Health's National Center for Complementary and Integrative Health (NCCIH) has announced the launch of an app for easy access to research-based information on the safety and effectiveness of herbal products.

Link Between Bullous Pemphigoid and Dipeptidyl Peptidase-4 Inhibitors

By Tyler Rice

The relationship between bullous pemphigoid and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

Intravenous Immunoglobulin Effective for Refractory Cutaneous Dermatomyositis

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Overall, 83% of patients experienced cutaneous DM improvement, which included 87% who received treatment for refractory skin disease alone and 81% who were treated for refractory skin/muscle/lung disease.

Hospitalization for Pemphigus Associated With Climate, Pollution

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Patients with pemphigus may benefit from avoidance of these environmental triggers.

Pain, Psychiatric Comorbidities Common in Patients With Klippel-Trenaunay Syndrome

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Klippel-Trenaunay syndrome is associated with the triad of capillary malformation, venous malformation, and/or lymphatic malformation, and limb overgrowth.

Overall Cancer Mortality Rates Decreasing for Men and Women

Cancer incidence rates have decreased among men but remained stable among women, while cancer death rates are decreasing for both men and women.

FDA Outlines Plan for Increasing Nonprescription Drug Availability

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The draft guidance, Innovative Approaches for Nonprescription Drug Products, applies to drugs under the New Drug Application (NDA) process and "is intended to extend that NDA pathway to include therapeutic indications that have not, historically, been available for use without a prescription," said Gottlieb in a press statement.

Jury Awards $4.62B in Johnson & Johnson Talcum Powder Lawsuit

The award includes $550 million in compensatory damages and $4.14 billion in punitive damages.

Fish Pedicure Causes Woman to Lose Toenails

A woman lost several toenails after a fish pedicure.

FDA Announces New Drug Shortages Task Force

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Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Distinction Between Inflammatory, Neuropathic Pruritis Is Relevant for Care

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Inflammatory pruritus may be more strongly associated with nociceptive symptoms than neuropathic pruritus.

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