Sildenafil and tadalafil can interact with nitrates found in some prescription drugs, such as nitroglycerin, and may lower blood pressure to dangerous levels.
Using data from the 2011 to 2016 National Vital Statistics System-Mortality files, the authors conducted a literal text analysis of death certificates to identify drugs mentioned as contributing to the cause of overdose death.
Clinical morphologic testing in addition to tissue biopsy and culture are critical in distinguishing NND from NF and treating appropriately.
Investigators examined whether a reduction in titration rates utilized in earlier trials would reduce the incidence of DRESS in patients taking cenobamate.
Medical science has made tremendous advances in personalized medicine. However, the American public is still struggling to understand the implications of these targeted treatments.
Multispectral optoacoustic tomography may become a promising and versatile tool for noninvasive diagnosis and monitoring of vascular malformations before and after treatment.
The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.
The members reached consensus on the use of a 5-point ordinal scale with descriptors provided via referenced electronic platforms.
The primary study outcome was the proportion of ulcers that healed within 20 weeks evaluated in the intention-to-treat population.
Higher incidence rates of subsequent BP have been reported in patients with brain and nervous system tumors than in those with other forms of cancer.
There is an urgent need to characterize these differences further to improve rates of outpatient dermatologic care use in disadvantaged populations.
Investigators sought to determine a scoring system for DiHS/DRESS that may be used to monitor severity and stratify risk for developing CMV disease and complications.
Trichloroacetic Acid Promising for the Treatment of Persistent Oral Mucosal Lesions in Pemphigus Vulgaris
The use of topical trichloroacetic acid 33% as treatment for persistent old refractory oral mucosal lesions in patients with pemphigus vulgaris (PV) may be promising.
The American Academy of Pediatrics, American College of Emergency Physicians, and Emergency Nurses Association have released updated guidelines for emergency care of injured and critically ill children.
Researchers reviewed the charts of 869 mothers and infants —in cases where infants were diagnosed with IH — between January 1, 1976 and December 31, 2010.
The 23andMe Personal Genome Service Pharmacogenetic Reports test can detect 33 variants for multiple genes, corresponding to more than 50 commonly prescribed medications and over-the-counter products.
Contrary to the advice most cancer patients receive, light or moderate use of topical agents before radiation treatment does not appear to increase the radiation dose to the skin.
Disease Extent, Nail Involvement May Predict Clinical Outcomes of Contact Immunotherapy for Alopecia Areata
Hair growth outcomes with contact immunotherapy for alopecia areata were associated with many factors and there was a significant variability in the criteria used.
Topical cantharidin showed high efficacy and safety for the treatment of warts, especially when used with podophyllotoxin and salicylic acid.
Newly approved treatment options for axillary hyperhidrosis give more opportunities for clinicians to provide personalized treatment for patients.
Liposomal hydroquinone has a significant therapeutic effect in patients with melisma but is not superior to conventional treatments.
The safety risk of dermatoscope magnets in patients with cardiovascular implanted electronic devices was examined.
Accepted manuscripts for observational studies have better adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist compared with rejected manuscripts.
Patients and their families are advocating for their right to access the latest medical research papers to help find potential treatments and understand health conditions.
Standard pen needles have an outer cover and removable inner needle cover, while safety pen needles have an outer cover and a fixed inner needle shield that is not removed before an injection.
The Company filed the sBLA last November following FDA feedback on two completed Phase 2 trials of Ruconest for prophylaxis of HAE attacks.
Investigators examine the association between pigmentation disorders and systemic involvement in patients with systemic sclerosis.
Patients with alopecia areata may have multiple risk factors for mental health disorders, including psychological distress and impaired quality of life.
The current study provides new clinical evidence for the optimization of drug therapy for pathologic scars.
Despite their advantages, many clinicians do not necessarily agree with the centrality or content of CPGs. Others — especially primary care physicians (PCPs) — are overwhelmed by the vast and ever-increasing numbers of guidelines issued by multiple societies.
African-American patients are more likely to have prurigo nodularis, which is associated with systemic, cardiovascular, and psychiatric comorbidities.
Topical once-daily glycopyrronium tosylate appears to provide a noninvasive, well-tolerated treatment option for patients with primary axillary hyperhidrosis.
Preliminary results from a Phase 1b proof-of-concept study showed that SYNT001 was associated with clinical improvement (as measured by Pemphigus Disease Area Index score) and induced a rapid reduction in lgG and circulating immune complex levels.
PF-06651600 is an investigational oral Janus kinase 3 (JAK3) inhibitor that is being evaluated in a Phase 2 study which will assess the treatment based on changes from baseline in Severity of Alopecia Tool (SALT) score.
Published trials have larger treatment effects than unpublished trials, while trials published in a language other than English have larger treatment effects versus those published in English.
Transcutaneous Pneumatic Injection More Effective, Less Painful for Lichen Simplex Chronicus Treatment
Since the amount injected and the air pressure can be set on the TPI device, the same amount of drug is delivered at the same depth to every injection site.
There are steps health care providers can take to better support cancer patients who do not speak English, are underinsured, and may face other major financial challenges.
All participants used the natural ingredient-based moisturizing cream and oatmeal-containing cream on randomly assigned legs twice daily for 3 weeks.
Emergency department visits for antibiotic adverse drug events in children account for 46.2 percent of emergency department visits for ADEs resulting from systemic medication.
Artificial intelligence in health care offers opportunities for early detection and triage, diagnostics and personalized medicine, and medical decision-making.
The approval was based on data from 4 clinical trials, including the 26-week Phase 3 HELP (Hereditary Angioedema Long-Term Prophylaxis) study that enrolled 125 patients with HAE aged ≥12 years.
ADVM-053 is being developed as a single‑administration treatment that could potentially provide sustained levels of the C1 esterase inhibitor protein, which may prevent breakthrough angioedema attacks.
The researchers theorized that education aimed at adolescents and delivered in a socially normalized group setting would be associated with durable QoL improvements.
The most common procedures that APPs performed in 2015 were destructions of benign neoplasms, biopsies, and destructions of malignant neoplasms.
Study assessments included the urticarial control test (UCT), the 7-day urticaria activity score (UAS7), angioedema activity score, and D-dimer levels.
Patients with TGM-1 deficiency may have chronic pronounced scaling of the skin with increased transepidermal water loss, as the TGM-1 enzyme is essential for facilitating the formation of the epidermal barrier, which prevents dehydration.
Dermal absorption is a more important pathway than inhalation for the intake of low-molecular-weight polycyclic aromatic hydrocarbons during barbecuing.
The mission of the NGC was to offer a source of objective, detailed information on clinical practice guidelines, and to further their dissemination, implementation, and use by health care professionals.
Several invasive medical procedures, including cardiovascular procedures and procedures of the skin and management of wounds, are associated with increased risk of infective endocarditis.
An Indianapolis teen suffered serious burns after his friends poured boiling hot water on him as part of fad called the "Hot Water Challenge."
The National Institutes of Health's National Center for Complementary and Integrative Health (NCCIH) has announced the launch of an app for easy access to research-based information on the safety and effectiveness of herbal products.
Overall, 83% of patients experienced cutaneous DM improvement, which included 87% who received treatment for refractory skin disease alone and 81% who were treated for refractory skin/muscle/lung disease.
Klippel-Trenaunay syndrome is associated with the triad of capillary malformation, venous malformation, and/or lymphatic malformation, and limb overgrowth.
Cancer incidence rates have decreased among men but remained stable among women, while cancer death rates are decreasing for both men and women.
The draft guidance, Innovative Approaches for Nonprescription Drug Products, applies to drugs under the New Drug Application (NDA) process and "is intended to extend that NDA pathway to include therapeutic indications that have not, historically, been available for use without a prescription," said Gottlieb in a press statement.
Dermatology Advisor Articles
- Limited Examination Detects Scabies With High Sensitivity
- Risk for Suicidal Ideation, Suicide Attempts Increased in Atopic Dermatitis
- Rosacea Associated With a Variety of Psychiatric Disorders
- How the Government Shutdown Affects FDA Activities
- AI Technology IDs Genetic Diseases by Analyzing Facial Photos
- The Gut-Face Connection in Rosacea: Exploring the Role of H pylori
- PRP May Reduce Visible Signs of Photoaging in Facial Rejuvenation
- Topical Methyl Estradiolpropanoate Safe, Effective for Treating Estrogen-Deficient Skin
- Knit One, Purl One: The Health Benefits of Knitting
- Risk for Suicidal Ideation, Suicide Attempts Increased in Atopic Dermatitis
- Treatment Satisfaction Lacking Among Patients With Psoriasis, Psoriatic Arthritis
- Comorbid Metabolic Syndrome, Psoriatic Arthritis Linked to Reduced Health-Related Quality of Life
- American College of Physicians Releases 7th Edition of Ethics Manual
- Investigational Cream Promising for Atopic Dermatitis
- Approximately 50 Percent of Patients Have Discussed Confidentiality with Physicans