Feature Article

Atopic Dermatitis: Practical Recommendations for Step-Up Therapy

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Although the step-care approach is the current standard of care, this approach is flawed in several ways with respect to achieving optimal outcomes.

The relative risk for healthcare-associated infections has decreased in the last 15 years due to improvements in awareness of risk associated with devices, infection control, and evidence-based practice regarding use of devices.

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FDA Awards Breakthrough Status to Atopic Dermatitis Treatment

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The safety and efficacy of PF-04965842 was evaluated in 375 individuals in a phase 3, randomized, double-blind, placebo-controlled trial.

Severe Atopic Dermatitis May Benefit From Fezakinumab

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Despite not reaching significance in the total population, the progressive clinical improvements seen in patients with severe AD suggest a therapeutic advantage.

Refractory Urticaria Benefits From Omalizumab

Omalizumab, alone or in combination with a short-term course of corticosteroids, is highly effective for the treatment of refractory chronic spontaneous urticaria.

Atopic Dermatitis May Improve With Add-On Lebrikizumab

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Twice-daily use of topical corticosteroids in all treatment arms, both prior to and during the study, impaired participants' ability to fully assess the efficacy of lebrikizumab.

Methotrexate, Azathioprine Safe for Long-Term Treatment of Atopic Dermatitis

Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to 5 years.

Atopic Dermatitis Linked to Increased Risk of Squamous Cell Carcinoma

Researchers advise dermatologists to discuss the importance of skin examinations and sunscreen use with patients with atopic dermatitis, who are an an increased risk of squamous cell carcinoma.

Chronic Hand Eczema Improved With Narrowband UVB, Psoralen UVA

For patients with chronic palmar hand eczema, both psoralen ultraviolet A and narrowband ultraviolet B treatment improve the severity of the disease.

Atopic Dermatitis Not Likely a Risk Factor for Cardiometabolic Disease

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Despite an increased prevalence, researchers found no significant evidence indicating atopic dermatitis as an independent risk factor for cardiometabolic disease.

Dupilumab Plus Concomitant Topical Corticosteroids Effective for Treatment-Refractory Atopic Dermatitis

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Patients with treatment-refractory atopic dermatitis may have good response to dupilumab plus concomitant topical corticosteroids.

Adult-Onset Atopic Dermatitis Has Distinct Phenotype

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Clinicians may be able to discern dermatitis phenotype based on the location of the lesions.

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