Dermatitis Latest News Archive

Link Between Atopic Dermatitis, Increased Risk for Extracutaneous Infections

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The presence of atopic dermatitis in both children and adults was associated with significantly higher odds for the development of ear infection, urinary tract infection, and strep throat.

Guidelines Developed for Managing Severe Atopic Dermatitis

Guidelines have been developed for the management of severe atopic dermatitis (AD).

Investigational Cream Promising for Atopic Dermatitis

Topical application of a transient receptor potential vanilloid subfamily, member 1 (TRPV1) antagonist may be an effective and safe treatment for patients with mild-to-moderate atopic dermatitis.

Risk for Suicidal Ideation, Suicide Attempts Increased in Atopic Dermatitis

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Pooling data from 11 of 14 relevant studies, patients with atopic dermatitis were 44% more likely to experience suicidal ideation compared with participants without atopic dermatitis.

Genetics, Clinical Characteristics Tied to Atopic Dermatitis Persistence in Childhood

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The investigators sought to explore heritable, environmental, and clinical factors linked to persistent atopic dermatitis based on 13 years of follow-up in an at-risk birth cohort.

Risk for Depression and Suicidal Ideation Elevated Among Patients With Atopic Dermatitis

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Patients with atopic dermatitis have a higher likelihood of clinical depression and suicidality.

Upadacitinib Improves Pruritus in Moderate to Severe Atopic Dermatitis

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Upadacitinib, a selective janus kinase-1 inhibitor, was associated with early improvements in pruritus in patients with moderate to severe atopic dermatitis.

Nickel Sensitivity Rose Significantly in North America From 1994 to 2014

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Researchers observed that allergic reactions to nickel have significantly increased in the last 20 years.

Oral JAK/SYK Inhibitor Granted Fast Track Designation for Atopic Dermatitis

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The Food and Drug Administration (FDA) has granted Fast Track designation to the investigational oral dual inhibitor, ASN002 (Asana BioSciences), for the treatment of moderate-to-severe atopic dermatitis.

Oral Food Challenge Failures Frequent in Patients With Atopic Dermatitis

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Investigators examined whether excessive food allergy testing in patients with atopic dermatitis might lead to food intolerance when certain foods are removed from the diet.

Correlation Between Age and Eczema Prevalence Examined

The mean cumulative lifetime prevalence of atopic eczema is 9.9 percent.

Subcutaneous Dupilumab Initiates Hair Regrowth in Patient With Alopecia Totalis, Atopic Dermatitis

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Dupilumab, commonly used for eczema, may be effective for hair regrowth in patients with alopecia totalis and atopic dermatitis.

Increased Risk of Depression, Suicide in Atopic Dermatitis

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The prevalence of depression in patients with atopic dermatitis was higher than in those without atopic dermatitis.

Treatment for Atopic Dermatitis Generally Decreases During Pregnancy

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Generally, women with AD decreased dermatologic therapy during pregnancy.

Dupilumab Gets Priority Review for Adolescent Atopic Dermatitis

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Dupixent is also being assessed in other allergic/inflammatory conditions, including pediatric atopic dermatitis, pediatric asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, grass allergy, and peanut allergy.

Prevalence of Atopic Dermatitis 7.3 Percent in U.S. Adults

The prevalence of atopic dermatitis is 7.3 percent among U.S. adults, and patients with atopic dermatitis and more severe disease have worse quality of life.

Ethnic Variations in Molecular Phenotypes of Patients With Atopic Dermatitis

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Investigators sought to characterize phenotypic variations in patients with atopic dermatitis who were African American and European American.

Improved Systemic, Cutaneous Abnormalities With Dupilumab in Atopic Dermatitis

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Dupilumab reduced cutaneous and systemic measures of inflammation and improved disease-severity scores in 4 weeks in moderate to severe atopic dermatitis.

Atopic Dermatitis Linked to Depression, Anxiety, and Suicidal Ideation

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Few available studies investigated the risk of completed suicide; however, most of these found a positive correlation between AD and completed suicide.

Variation of Staphylococcus aureus Clonal Complex Type Linked to Worse Disease Activity in Atopic Dermatitis

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Of patients who were colonized at both visits, 51.9% remained colonized with the same CC-type at follow-up.

Use of Bee Venom for Topical Treatment in Patients With Atopic Dermatitis

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The use of bee venom and its major component, melittin, has proven suitable as an epicutaneous application for the treatment of atopic dermatitis.

Menthoxypropanediol Provides Itch Relief in Atopic Dermatitis

By Dermatology Advisor Contributing Writer

The participants were administered a skin care formulation containing menthoxypropanediol.

Atopic Dermatitis Likely Not Associated With Cardiometabolic Disease

By Dermatology Advisor Contributing Writer

Atopic dermatitis was not found to be an independent risk factor for cardiometabolic disease in this meta-analysis.

Hypersensitivity to Allergens in Personal Care Products More Common in Atopic Dermatitis

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Polysensitization was reported significantly more often in patients with atopic dermatitis vs those without.

Individuals With Atopic Dermatitis More Likely to Have Antibody Response to S Aureus Superantigens

By Dermatology Advisor Contributing Writer

An immunoglobulin E (IgE) antibody response to Staphylococcus aureus superantigens is more common among individuals with atopic dermatitis than healthy controls.

Dupilumab Beneficial in Adolescent Patients With Moderate to Severe Atopic Dermatitis

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The Phase 3 trial enrolled 251 patients aged 12-17 years old with moderate-to-severe atopic dermatitis, whose disease was not adequately controlled by prescription topical medications or for whom topical treatment was medically inadvisable.

Low Quality of Life, High Disease Burden Seen in Atopic Dermatitis

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The study findings support the heavy burden that atopic dermatitis places on patients, particularly those with moderate and severe disease.

Stratum Corneum Samples Effective for Immune Response Analysis in Pediatric Atopic Dermatitis

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Some aspects of pathophysiologic mechanisms may differ in children with atopic dermatitis with light skin types vs those with dark skin types.

Dupilumab for Atopic Dermatitis: Is the Increased Cost Worth It?

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Dupilumab therapy provided an additional 1.91 quality-adjusted life years during the remaining lifetime of a patient compared with usual care.

Tapinarof Cream Safe, Effective for Atopic Dermatitis

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The proportion of participants who achieved EASI75 at week 12 was highest among the tapinarof groups.

Doctors Can Help Children, Teens Adhere to Eczema Treatment Plan

Physicians can create an adherence protocol for patients, particularly children and teens, receiving treatment for atopic dermatitis.

Nemolizumab Effective for Moderate, Severe Atopic Dermatitis Inadequately Controlled With Topical Therapy

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For patients with moderate to severe atopic dermatitis inadequately controlled with topical therapies, the anti-IL-31 receptor A humanized monoclonal antibody nemolizumab may provide benefit.

Utility of Antimicrobial Textiles Explored for Atopic Dermatitis

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Functional textiles that rapidly lose their deliverable antimicrobial activity in vitro are not advisable for the AD population.

Atopic Dermatitis Places Heavy Burden on Patients

Atopic dermatitis (AD) dramatically impacts the quality of life of patients.

Pediatric Atopic Dermatitis Associated With Cataract Development

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The investigators sought to explore the association of atopic dermatitis with subsequent cataract development and cataract surgery in a Korean pediatric population.

Adolescents With Atopic Dermatitis Often Deviate From Prescribed Medication Regimens

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The investigators sought to explore adolescents' experiences with, preferences for, and beliefs about their atopic dermatitis treatment.

High Patient Burden With Moderate-to-Severe Atopic Dermatitis

Patients with moderate/severe atopic dermatitis have higher patient-reported burden than those with mild atopic dermatitis, regardless of disease control.

Substantial Financial Burden Exists for Emergency Department Visits for Atopic Dermatitis

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The investigators sought to determine the prevalence of, risk factors associated with, and cost of ED care among patients with atopic dermatitis or eczema in the United States by analyzing a 20% sample of ED visits throughout the country.

Severe, Active Atopic Eczema Linked to Increased Cardiovascular Risk

The investigators sought to explore whether adults with atopic eczema are at a higher risk for cardiovascular disease, and whether the risk varies based on severity of the disease and the activity of the condition over time.

Elevated Risk of Osteoporosis, Osteopenia in Adults With Atopic Dermatitis

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Patients with atopic dermatitis should be encouraged to increase their level of physical activity, partake in adequate weight-bearing exercises, and have a sufficient intake of calcium and vitamin D.

Severe Atopic Eczema Tied to Higher CV Disease Risk

Adults with severe atopic eczema are at increased risk of cardiovascular disease.

Cold Weather Prompts More Health Care Utilization in Atopic Dermatitis

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In AD, associations between AD healthcare utilization and hours of cloud cover were generally positive, whereas hours of bright sunlight were generally inversely associated with health care utilization.

Positive Results for Dupilumab in Teen Atopic Dermatitis Trial

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The primary endpoint was the proportion of patients with an IGA score of 0 (clear) or 1 (almost clear) at Week 16.

Shower Cream, Body Lotion Combo Improves Atopic Dry Skin

A shower cream and a body lotion with physiological lipids are effective in improving skin hydration in patients with dry skin.

Atopic Dermatitis Effectively Treated With Topical Microbiome Transplantation

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This finding could lead to the development of a low-cost atopic dermatitis therapy that does not require daily application.

No Clinical Benefit Seen for Bath Emollients in Childhood Eczema

Researchers examined the clinical effectiveness and cost-effectiveness of emollient bath additives in the management of childhood eczema.

Concomitant Allergic Dermatitis, Polysensitization Common in Tough-to-Treat Atopic Dermatitis

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Patients with difficult-to-treat AD often experience concomitant, multiple contact allergies, which may be why their AD actually becomes a difficult-to-treat disease.

Birch Pollen-Related Foods Can Trigger Dermatitis Reactions

In patients with atopic dermatitis and birch pollen allergy, consumption of birch pollen-related foods is associated with allergic reactions and deterioration of AD.

Skin Hypersensitivity in Infants Decreased With Yogurt Consumption

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When testing for sensitivity to histamine, larger swelling sizes were recorded for infants with eczema and atopic dermatitis compared with infants without those conditions.

Emollient Use Helps Reduce Symptoms of Atopic Dermatitis

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Continuous treatment with emollient maximizes clinical benefit and should be considered as a first line-treatment for pediatric AD.

Herbal Supplement, Topical Treatment Available for Eczema, Urticaria

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Harmony Herbal announced the launch of Skin Therapy Calm over-the-counter (OTC) topical and Calm + Detox supplement duo for the symptomatic relief of rash, eczema, and dermatitis.

Age at Eczema Onset Influences Risk for Pediatric Asthma

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Researchers hypothesized that the age of asthma onset in children with early-onset eczema would be younger compared with children with asthma and no eczema.

Dupilumab Effective for Atopic Dermatitis in Patients With Comorbid Asthma

By Pulmonology Advisor Contributing Writer

A recent study showed that the administration of dupilumab was associated with comparable/significant improvement in signs and symptoms of atopic dermatitis in patients with or without comorbid asthma.

Baricitinib 4 mg Effective for Moderate to Severe Atopic Dermatitis

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The proportion of participants in the treatment groups who achieved EASI-50 was statistically significant compared with placebo as early as 4 weeks after beginning treatment.

Anti-Inflammatory Moisturizer May Relieve Facial Dermatitis Symptoms

Researchers compared the efficacy of moisturizer containing 4-t-butylcyclohexanol and licochalcone A to 0.02% triamcinolone acetonide (TA) for treating facial dermatitis.

FDA Awards Breakthrough Status to Atopic Dermatitis Treatment

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The safety and efficacy of PF-04965842 was evaluated in 375 individuals in a phase 3, randomized, double-blind, placebo-controlled trial.

Severe Atopic Dermatitis May Benefit From Fezakinumab

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Despite not reaching significance in the total population, the progressive clinical improvements seen in patients with severe AD suggest a therapeutic advantage.

Refractory Urticaria Benefits From Omalizumab

Omalizumab, alone or in combination with a short-term course of corticosteroids, is highly effective for the treatment of refractory chronic spontaneous urticaria.

Atopic Dermatitis May Improve With Add-On Lebrikizumab

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Twice-daily use of topical corticosteroids in all treatment arms, both prior to and during the study, impaired participants' ability to fully assess the efficacy of lebrikizumab.

Methotrexate, Azathioprine Safe for Long-Term Treatment of Atopic Dermatitis

Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to 5 years.

Atopic Dermatitis Linked to Increased Risk of Squamous Cell Carcinoma

Researchers advise dermatologists to discuss the importance of skin examinations and sunscreen use with patients with atopic dermatitis, who are an an increased risk of squamous cell carcinoma.

Chronic Hand Eczema Improved With Narrowband UVB, Psoralen UVA

For patients with chronic palmar hand eczema, both psoralen ultraviolet A and narrowband ultraviolet B treatment improve the severity of the disease.

Atopic Dermatitis Not Likely a Risk Factor for Cardiometabolic Disease

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Despite an increased prevalence, researchers found no significant evidence indicating atopic dermatitis as an independent risk factor for cardiometabolic disease.

Dupilumab Plus Concomitant Topical Corticosteroids Effective for Treatment-Refractory Atopic Dermatitis

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Patients with treatment-refractory atopic dermatitis may have good response to dupilumab plus concomitant topical corticosteroids.

Adult-Onset Atopic Dermatitis Has Distinct Phenotype

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Clinicians may be able to discern dermatitis phenotype based on the location of the lesions.

Atopic Dermatitis Severity Associated With IgG Responses to S. Aureus Antigens

In young children, atopic dermatitis severity is linked to an immunoglobulin response directed against Staphylococcus aureus antigens with mainly immune-modulatory functions.

Chronic Spontaneous Urticaria Disease Activity, Treatment Response Linked to C-Reactive Protein Levels

C-reactive protein levels are frequently elevated in patients with chronic spontaneous urticaria, and these elevations are relevant and potentially useful in management of the condition.

Inadequate Disease Control Common in Atopic Dermatitis

Inadequately controlled patients had worse disease-specific quality of life, higher level of work impairment, greater itch, and more sleep interference with daily living.

Flexural Dermatitis Risk Tied to Breastfeeding Duration

Prolonged and exclusive breastfeeding may reduce the risk of flexural dermatitis in adolescence, but does not affect lung function or questionnaire-derived measures of asthma or atopic eczema.

Atopic Dermatitis in Infancy Associated With S Aureus Colonization

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Atopic dermatitis is the most common skin disease in children and occurs within the first year of life in 60% of cases.

Eczema Linked to Mixed Feeding Modes in Infants

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Current infant feeding trends that promote pumping and feeding and mixed feeding modes may be of concern.

Characterizing Staphylococcus Aureus Colonization During Eczema Disease Flares

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Clinical studies have demonstrated an association between S aureus and the pathogenesis of AE, with affected persons typically prone to colonization.

Assessing Safety, Efficacy of Methotrexate for Atopic Dermatitis

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Researchers uncovered a dose-dependent relationship for the treatment of atopic dermatitis with methotrexate.

Consensus Statement Issued for Systemic Corticosteroids Use in Atopic Dermatitis

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Systemic corticosteroid medications tend to be overprescribed for patients with atopic dermatitis, and the International Eczema Council released a consensus statement on when they should be prescribed.

Quality of Life in Atopic Dermatitis Improved With Novel Biologic Medication

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A new class of biologic medications was found to improve clinical signs and symptoms of moderate-to-severe atopic dermatitis.

Biomarkers May Predict Chronic Urticaria Resolution

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Although pediatric chronic urticaria is associated with a low rate of resolution, new research suggests the presence of certain biomarkers may help in predicting disease resolution.

Eczema Health Care Utilization Down in Black Children

The likelihood of reporting an ambulatory visit for eczema was lower for non-Hispanic blacks than whites.

Benzalkonium Chloride: A Skin Irritant and Sensitizer in Patients With Dermatitis

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Products that contain benzalkonium chloride, a commonly used preservative in various personal care products, should be utilized with caution in patients with compromised skin barriers.

Atopic Dermatitis Reduced With Bacillus Calmette-Guerin Vaccine

The BCG vaccination may reduce the risk of allergic diseases within 7 days of birth.

Crisaborole Ointment Safe for Treating Atopic Dermatitis

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Crisaborole ointment was found to be a safe treatment of mild to moderate atopic dermatitis with a low frequency of treatment-related adverse effects.

Probiotics in Infancy Ineffective in Preventing Eczema and Asthma Later in Life

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Supplementing high-risk infants with probiotics does not help prevent future eczema or asthma development, new research suggests.

High Rate of Alcohol Use Disorder in Atopic Dermatitis

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Physicians should ask patients with eczema about their alcohol usage.

Sodium Hypochlorite Effective Against S. aureus Isolates in Atopic Dermatitis

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The eradication of S. aureus biofilms in vitro was observed at concentrations ranging from .01% to .16%.

IgE-Specific Testing Helps Improve Atopic Dermatitis Outcomes

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Identification of specific antigens via IgE quantitative assaying of allergies can guide patients with atopic dermatitis to make lifestyle changes to improve outcomes.

Seborrheic Dermatitis More Common in Males, Darker Skin

Seborrheic dermatitis is a common inflammatory condition in middle-aged and elderly individuals, particularly in males and those with darker skin.

Pediatric Eczema Slightly Improved With Silk Garments

Some children report limited improvement in atopic eczema as a result of wearing silk garments.

Quality of Life in Atopic Dermatitis Improved With Dupilumab

For patients with atopic dermatitis, dupilumab improves health-related quality-of-life and is associated with improved clinical outcomes.

Eczema Incidence Not Reduced With Probiotics in Infancy

Giving infants probiotics within the first 6 months of life doesn't reduce incidence of eczema at 2 or asthma at 5.

Atopic Dermatitis Patients Face Greater Psychological Risks

In individuals with atopic dermatitis, depression, anxiety, and suicidal ideation are more common.

BID Pimecrolimus for 1 Month Best for Facial Seborrheic Dermatitis

For patients with facial seborrheic dermatitis, the best regimen seems to be primecrolimus 1% cream, twice a day for 4 weeks.

Adverse Events Related to Cosmetics Go Unreported

Cosmetic related health problems are underreported.

EpiCeram Now Available in 4-Pack of Airless Pumps

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EpiCeram is now available in airless pump packs.

Most Commonly Prescribed Medications for Atopic Dermatitis

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The most commonly prescribed medications for atopic dermatitis seems to be topical corticosteroids.

Risk of Atopy Not Influenced by Low Vitamin D Levels

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SNPs associated with low vitamin D levels didn't confer an increased risk of asthma, atopic dermatitis, or IgE.

Stevens Johnson Syndrome Linked to Sleep Disorder Treatment

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A patient developed Stevens-Johnson Syndrome shortly after using armodafinil for a sleep disorder.

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