Pranshu Bansal

Myelodysplastic Syndromes I. What every physician needs to know. Myelodyplastic Syndromes (MDS) is an acquired marrow failure syndrome caused by accumulated mutations in pluripotent stem cells responsible for production of blood cells. The mutations lead to ineffective dysplastic hematopoiesis. Most cases of MDS arise denovo with a smaller number (~15%) secondary to exposure to DNA-damaging…

Chronic myeloid leukemia I. What every physician needs to know. Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN). MPNs are stem cell-derived clonal disorders with proliferation of one or more of the components of myeloid lineage. CML patients carry a fusion gene called breakpoint cluster region-abelson (BCR-ABL) fusion gene derived from a…