Mark Thoelke

All articles by Mark Thoelke

Addison's disease (primary adrenocortical insufficiency)

I. What every physician needs to know. Addison’s disease, or primary adrenocortical insufficiency, is characterized by a deficiency in endogenous cortisol production secondary to destruction or dysfunction of the adrenal cortices. In the United States (US), Addison’s disease is most commonly caused by autoimmune destruction (80% of spontaneous cases), but also has infectious, vascular, metastatic,…

Weakness; Focal

Focal weakness I. Problem/Condition. Weakness is among the most common complaints of patients presenting to the clinic and the hospital, Generalized weakness is very nonspecific, with a long list of potential causes. However, pursuing a rigorous history and neurologic exam using a framework for localizing the source of weakness can help to narrow the differential…

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