F. Ryan Caballes

All articles by F. Ryan Caballes

How can I be sure that the patient has chronic cutaneous porphyria? Unlike acute porphyrias, which may be clinically indistinguishable, cutaneous porphyrias may be more easily identified from each other in the clinical setting due to some of their unique properties. Together with the occasional photosensitivity of HCP (hereditary coproporphyria) and VP (variegate porphyria), cutaneous…

How can I be sure that the patient has acute porphyrias? Porphyrias are a group of nine metabolic disorders associated with enzymatic defects of heme biosynthesis, which may lead to overexcretion of porphyrins or their precursors (ALA and PBG) in urine or feces (Table I). All are in-born errors of metabolism, except for porphyria cutanea…