Bob Silver

Antiphospholipid Syndrome (APS) 1. What every clinician should know Clinical features and incidence Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies recognizing epitopes expressed by negatively charged phospholipids, proteins or a phospholipid-protein complex. The true epitope in vivo is unknown. aPL are associated with a variety of medical and obstetric problems. Medical problems include:…

Inherited thrombophilia. Prothrombotic disorder. Predisposition to blood clots. 1. What every clinician should know Thrombophilias are a heterogeneous group of conditions that dispose individuals to thromboembolic events (VTE). Most of these are venous thromboses. Normal hemostasis involves a delicate balance of procoagulant proteins that promote clot formation in case of bleeding or damaged endothelium and…