Waldenstrom's macroglobulinemia I. What every physician needs to know. Waldenstrom’s macroglobulinemia (WM) is a lymphoproliferative disorder characterized by bone marrow infiltration and clonal proliferation of B-lymphocytes that produce IgM. II. Diagnostic Confirmation: Are you sure your patient has Waldenstrom's macroglobulinemia? WM can be asymptomatic or symptomatic. To be diagnosed with the disease, there must be…
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