Hairy Cell Leukemia I. What every physician needs to know. Hairy cell leukemia (HCL) is a rare and highly treatable B cell lymphoproliferative disorder. It is characterized by leukemic hairy cells of specific immunophenotype having strongly positive cytoplasm for tartrate-resistant acid phosphatase (TRAP), massive splenomegaly and very little or no involvement of lymph nodes. It…
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