Acne Latest News Archive
The approval was based on data from 2 large, multicenter, randomized, double-blind, placebo-controlled Phase 3 trials involving patients with moderate to severe facial acne vulgaris.
Lower doses of spironolactone seem to be effective and may be an appropriate option for those patients with tolerability issues.
The approval was based on 2 double-blind clinical trials involving 1640 patients 9 years of age and older with moderate to severe acne vulgaris.
The researchers theorized that education aimed at adolescents and delivered in a socially normalized group setting would be associated with durable QoL improvements.
Negative clinical outcomes experienced during the recruitment period prompted the researchers to conduct an interim analysis, which resulted in discontinuation of the study.
It is hoped that use of the tool will help to improve the management of HS and enhance patients' feeling of control over their illness.
After a mean 22.7 months of follow-up, participants showed an 81% reduction in acne lesions, with 60% of participants having 90% or greater reduction.
The researchers determined efficacy based on the change in facial investigator global assessment and changes in total, inflammatory, and noninflammatory lesion counts between baseline and week 16.
The study included women with acne who were started on either spironolactone (n=6684) or an oral tetracycline-class antibiotic (n=31,614) between 2010 and 2016.
The male patient presented in 2009 with a "3-year history of multiple interconnecting comedones in the axilla and inguinal regions, as well as scarring from previous lesions."
5-Aminolevulinic Acid 5% Thermosetting Gel Photodynamic Therapy Effective, Tolerable for Inflammatory Acne
The investigators sought to evaluate the efficacy, safety, and tolerability of red-light (630 nm) PDT with a new 5-aminolevulinic acid "low-dose" topical gel formulation (5%) for the treatment of patients with inflammatory mild to moderate acne vulgaris.
Outcomes were examined in 2 randomized, double-blind, placebo-controlled, parallel-group clinical trials: PIONEER I (ClinicalTrials.gov identifier: NCT01468207) and PIONEER II (ClinicalTrials.gov identifier: NCT01468233).
Although HAAT is not typically used as a first-line systemic therapy in women with acne, HAAT usage is linked to shorter cumulative antibiotic duration.
The investigators selected 6 different black fabrics for analysis: 100% polyester fleece (100% polyester), 100% cotton, 75% nylon/25% spandex, 100% rayon, and 55% linen/45% rayon.
Adherence to guidelines on the part of pediatricians who care for patients with acne has the potential to improve treatment provided in the primary care setting, enhance patient satisfaction, and permit greater access to dermatologists and pediatric dermatologists.
Dermatology-specific and acne-specific instruments have better sensitivity in assessing successful treatment interventions than generic instruments.
Hidradenitis suppurativa is more common in patients with axial spondyloarthritis compared with the general population.
Medical nutrition therapy may be a practical treatment option for patients with acne, based on the diet-induced endocrine effects on acne-promoting pathways described in this study.
Treatment with the combination gel + oral doxycycline was associated with a 66.2% reduction in inflammatory lesions, a 58.7% reduction in non-inflammatory lesions, and a 62.6% reduction in total lesions at Week 12 vs baseline (P <.0001).
Patients with early-onset hidradenitis suppurativa should be reassured by the fact that no difference in the severity of hidradenitis suppurativa was observed between those with onset of disease at ≤17 years of age and those with onset during their adult years.
Recognizing the increased need for antibiotic stewardship, the researchers consider HAAT to be a useful alternative to systemic antibiotic therapy that is effective and well tolerated among women with inflammatory acne.
Additional studies are warranted, particularly among those with severe acne, confirm these results and evaluate the best treatment regimen for further reducing atrophic acne scars.
On subject questionnaire, 83.2% participants reported being "satisfied" or "very satisfied" with study treatment, and 90.2% subjects reported moderate symptomatic improvement.
Although this study is limited by its small sample size, the evidence suggests that oral sarecycline 1.5 mg/kg administered once daily may be a viable treatment option for moderate to severe acne.
Among the somatic comorbidities evaluated were acne, type 1 diabetes, Down syndrome, hypertension, inflammatory bowel diseases, inflammatory joint diseases, metabolic syndrome, obesity, pilonidal sinus, and thyroid disorders.
Physician-level interventions designed to improve primary adherence with acne medications may have an impact on nonadherence with expensive medications.
The investigators sought to determine the frequency of complications and adverse effects linked to the use of superficial chemical peels in patients with skin types III to VI.
The results obtained from the study were not deemed to be sufficiently valid to predict acne symptoms, since aberrant expression of these skin proteins must indicate some specific tissue conditions.
Since patients with HS have a higher risk for SUD, periodic screening for substance abuse may be beneficial in this population.
Close attention to first month follow-up via telephone and message reminders may help increase the successful initiation and completion of isotretinoin treatment.
The role played by androgens in HS and the potential benefit of anti-androgen treatment in these patients warrants additional investigation.
These findings suggest that physicians and dermatologists monitor mood symptoms in patients with acne and refer patients to a psychiatrist when needed.
The Food and Drug Administration has accepted for review the New Drug Application for a once-daily medication for the treatment of moderate to severe acne vulgaris in patients ≥9 years of age.
The researchers found that in both male and female patients, serum homocysteine levels were significantly higher compared to the healthy control group.
The opportunity exists to develop resiliency training programs and to explore their role in mitigating stress levels and depressive symptoms among patients with HS.
An international group of expert dermatologists with an interest in acne research and education have developed a consensus statement on the effective management of acne.
A 6- to 12-week course of intravenous ertapenem was shown to result in immediate improvement of hidradenitis suppurativa symptoms for all patients and in varying rates of durable response following treatment completion.
With the use of dietary supplements increasing in adolescents, physicians should be sure to counsel patients on the risks of concurrent use with isotretinoin treatment.
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