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Case Report: Skin Mottling Linked to Infection

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A 44-year-old woman presents to her local emergency department after 5 days of persistent fever, productive cough, and worsening dyspnea on exertion.

The relative risk for healthcare-associated infections has decreased in the last 15 years due to improvements in awareness of risk associated with devices, infection control, and evidence-based practice regarding use of devices.

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FDA Outlines Plan for Increasing Nonprescription Drug Availability

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The draft guidance, Innovative Approaches for Nonprescription Drug Products, applies to drugs under the New Drug Application (NDA) process and "is intended to extend that NDA pathway to include therapeutic indications that have not, historically, been available for use without a prescription," said Gottlieb in a press statement.

Jury Awards $4.62B in Johnson & Johnson Talcum Powder Lawsuit

The award includes $550 million in compensatory damages and $4.14 billion in punitive damages.

Fish Pedicure Causes Woman to Lose Toenails

A woman lost several toenails after a fish pedicure.

FDA Announces New Drug Shortages Task Force

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Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Distinction Between Inflammatory, Neuropathic Pruritis Is Relevant for Care

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Inflammatory pruritus may be more strongly associated with nociceptive symptoms than neuropathic pruritus.

WHO Calls for Renewed Effort to Combat Chronic Disease

The World Health Organization Independent High-Level Commission has proposed six recommendations to address the growing epidemic of non-communicable diseases.

Link Between Oral Diabetes Medications and Bullous Pemphigoid

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Finnish investigators evaluated the link between diabetes medications other than DPP-4 inhibitors and the risk for BP.

Novel Treatment for Primary Axillary Hyperhidrosis Gets FDA Approval

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The approval was supported by Phase 3 data from the ATMOS-1 and ATMOS-2 trials which evaluated the absolute change from baseline in sweat production after treatment with Qbrexza, and the proportion of patients who achieved ≥4-point improvement from baseline in their sweating severity (as measured by the Axillary Sweating Daily Diary [ASDD]).

Cinryze Approved for Pediatric Patients With Hereditary Angioedema

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The approval was based on data from a randomized, single-blind, multicenter, dose-ranging, crossover study which evaluated the safety and efficacy of Cinryze in 12 pediatric patients (7 to 11 years old).

Antibiotic-Methotrexate Combo Leads to Serious Side Effects in RA Patient

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The case involved a 68-year-old female patient with rheumatoid arthritis on methotrexate 10mg weekly who presented to the emergency department with complaints of lethargy and weakness after being prescribed a 2-week course of TS for a bacterial skin infection.

FDA to Review Afamelanotide NDA for Erythropoietic Protoporphyria

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Scenesse (Clinuvel Pharmaceuticals) is a bimonthly, subcutaneous dose of afamelanotide 16mg.

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

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In a press release Dr. David Young, CEO of Processa said "We plan to begin our clinical studies in 2018 and to accelerate the development of PCS499 in order to provide clinical benefit to [necrobiosis lipoidica] patients as soon as possible."

Single-Use Lidocaine 1% Ampules Now Available

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The ampules are available immediately.

Narrow-Band UVB May Have Curative Potential for Mycosis Fungoides

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Narrow-band ultraviolet B is a disease-modifying treatment with curative potential for patients with stage I mycosis fungoides.

Topical Rapamycin Effective for TSC-Related Facial Angiofibromas

Researchers examined the efficacy and safety of topical rapamycin for TSC-related facial angiofibromas in a study involving 179 patients.

Rituxan Approved for Moderate to Severe Pemphigus Vulgaris

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The approval was based on data from the Ritux 3 trial (N=90) which compared rituximab + short-term oral prednisone (Ritux 3 regimen) to oral prednisone alone as a first-line treatment for patients with newly diagnosed moderate to severe PV.

Compression Plus Early Ablation Tied to Faster Leg Ulcer Healing

Early endovenous ablation of superficial venous reflux results in faster healing of venous leg ulcers and more time free from ulcers, compared with deferring endovenous ablation until after ulcer healing.

Case Shows Biotin Can Interfere With Multiple Endocrine Tests

Biotin, which is included in many hair, skin, and nail growth over-the-counter products, can affect multiple hormone levels.

Chronic Corticosteroid Use in Frontal Fibrosing Alopecia May Induce Vascular Changes

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Vascular structures were detected more frequently among chronic TC users vs nonusers, including thin arborizing vessels and thick arborizing vessels and extravasated hemorrhages.

Should Genealogy Data Be Used for Criminal Justice Purposes?

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Informed consent, privacy, and justice concerns are 3 issues that should be addressed before the use of online genealogy data in criminal cases becomes widely adopted.

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