Feature Article

Atopic Dermatitis: Practical Recommendations for Step-Up Therapy

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Although the step-care approach is the current standard of care, this approach is flawed in several ways with respect to achieving optimal outcomes.

The relative risk for healthcare-associated infections has decreased in the last 15 years due to improvements in awareness of risk associated with devices, infection control, and evidence-based practice regarding use of devices.

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Methotrexate, Azathioprine Safe for Long-Term Treatment of Atopic Dermatitis

Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to 5 years.

Atopic Dermatitis Linked to Increased Risk of Squamous Cell Carcinoma

Researchers advise dermatologists to discuss the importance of skin examinations and sunscreen use with patients with atopic dermatitis, who are an an increased risk of squamous cell carcinoma.

Chronic Hand Eczema Improved With Narrowband UVB, Psoralen UVA

For patients with chronic palmar hand eczema, both psoralen ultraviolet A and narrowband ultraviolet B treatment improve the severity of the disease.

Atopic Dermatitis Not Likely a Risk Factor for Cardiometabolic Disease

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Despite an increased prevalence, researchers found no significant evidence indicating atopic dermatitis as an independent risk factor for cardiometabolic disease.

Dupilumab Plus Concomitant Topical Corticosteroids Effective for Treatment-Refractory Atopic Dermatitis

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Patients with treatment-refractory atopic dermatitis may have good response to dupilumab plus concomitant topical corticosteroids.

Adult-Onset Atopic Dermatitis Has Distinct Phenotype

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Clinicians may be able to discern dermatitis phenotype based on the location of the lesions.

Atopic Dermatitis Severity Associated With IgG Responses to S. Aureus Antigens

In young children, atopic dermatitis severity is linked to an immunoglobulin response directed against Staphylococcus aureus antigens with mainly immune-modulatory functions.

Chronic Spontaneous Urticaria Disease Activity, Treatment Response Linked to C-Reactive Protein Levels

C-reactive protein levels are frequently elevated in patients with chronic spontaneous urticaria, and these elevations are relevant and potentially useful in management of the condition.

Inadequate Disease Control Common in Atopic Dermatitis

Inadequately controlled patients had worse disease-specific quality of life, higher level of work impairment, greater itch, and more sleep interference with daily living.

Flexural Dermatitis Risk Tied to Breastfeeding Duration

Prolonged and exclusive breastfeeding may reduce the risk of flexural dermatitis in adolescence, but does not affect lung function or questionnaire-derived measures of asthma or atopic eczema.

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